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Indications

Dapsone is an antibiotic used to treat various bacterial and skin diseases. It belongs to the class of drugs known as sulfones and works by decreasing the growth of bacteria and reducing inflammation.

Dapsone is commonly used in combination with other drugs to treat conditions such as leprosy (Hansen’s disease), dermatitis herpetiformis, and Pneumocystis jiroveci pneumonia.

Medications for heartburn/reducing stomach acid (such as large amounts of antacids, ranitidine, famotidine), or didanosine may prevent full absorption of dapsone into your bloodstream, reducing its effectiveness.

Use and Dosage

Take this medication by mouth with or without food, usually once daily or as directed by your doctor. Separate your dose of dapsone from your doses of any of these products by at least 2 hours.

If you are taking dapsone for a skin disorder, your doctor may start you on a low dose of dapsone and gradually adjust your dose to control your disease. If you are taking this medication to treat Hansen’s disease or to prevent infections due to HIV, the drug is usually taken for years or life.

Dosage is based on your medical condition and response to treatment. In children, the dosage is also based on age and weight.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Side Effects

Dapsone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• Upset stomach
• Vomiting

If you experience any of the following symptoms, call your doctor immediately:

• Sore throat
• Fever
• Rash
• Yellowing of the skin or eyes
• Unusual bruising

Cautions

Before taking Dapsone:

• Tell your doctor and pharmacist if you are allergic to dapsone, sulfa drugs, phenylhydrazine, naphthalene, niridazole, nitrofurantoin, primaquine, or any other drugs.
• Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aminobenzoate potassium (Potaba), aminobenzoic acid, clofazimine (Lamprene), didanosine (Videx), probenecid (Benemid), pyrimethamine (Daraprim), rifampin (Rifadin), trimethoprim (Bactrim, Cotrim, Septra), or vitamins.
• Tell your doctor if you have or have ever had anemia or liver disease.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Dapsone, call your doctor.
• Plan to avoid unnecessary or prolonged exposure to sunlight and wear protective clothing, sunglasses, and sunscreen. Dapsone may make your skin sensitive to sunlight.

Form and Strengths

Dapsone is available in the following form and strengths:

Dapsone Tablet:

• 100mg

FAQ

What special dietary instructions should I follow?

Dapsone may cause an upset stomach. Take dapsone with food or milk.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Why is this medication prescribed?

Dapsone is used to treat leprosy and skin infections.

Resources:

1. https://medlineplus.gov/druginfo/meds/a682128.html
2. https://www.webmd.com/drugs/2/drug-6744/dapsone-oral/details
3. https://www.ncbi.nlm.nih.gov/books/NBK470552/