Galvus Met (Vildagliptin/Metformin)

Indications

Galvus Met is a combination drug used for the treatment of type 2 diabetes mellitus in adults. It is prescribed along with a proper diet and exercise. By controlling your blood sugar level, Galvus Met helps avoid complications of diabetes, such as heart attack, stroke, blindness, nerve problems, loss of limbs, and kidney damage.

Galvus contains two active ingredients, Vildagliptin (DPP-4 inhibitor) and Metformin (biguanide) that work together to lower high blood sugar levels in patients with diabetes. The drug works by increasing insulin secretion and reducing the amount of glucose produced in the liver, thereby improving the body's ability to regulate blood sugar levels.

Use and Dosage

Galvus Met tablet should be taken exactly as prescribed by your doctor. It is typically taken orally, with or without food once or twice daily, depending on the directions of your physician. However, take it with a meal to reduce the risk of stomach upset. The tablet should be swallowed whole with a glass of water, do not crush, or chew the tablet.

The dosage may vary depending on the severity of your condition and your response to the treatment. Take the tablet at the same time every day to maintain consistent blood sugar levels. Do not stop taking Galvus Met without consulting your doctor first.

If you miss a dose of Galvus Met, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Side Effects

Common Side Effects of Galvus Met (Vildagliptin/Metformin):

• Nausea
• Vomiting
• Stomachache
• Diarrhea
• Headache
• Trembling
• Dizziness
• Loss of Appetite
• Metallic taste
• Hypoglycemia

Serious Side Effects of Galvus Met (Vildagliptin/Metformin):

• A burning sensation in the chest
• Dark urine
• Irregular heartbeat
• Joint pain
• Persistent vomiting
• Seizure
• Severe abdominal pain
• Severe weakness
• Signs of high blood sugar or hyperglycemia (increased thirst, frequent urination, increased hunger, blurred vision, fruity-smelling breath, tingling or numbness in the extremities)
• Signs of low blood sugar or hypoglycemia (shakiness, dizziness, palpitations, confusion, irritability, difficulty concentrating)
• Swelling of the extremities

Forms and Strength

Galvus Met (Vildagliptin/Metformin) is available in the following forms and strength:

Galvus Met: Tablet

• 50/500mg

Vildagliptin/Metformin: Tablet

• 50/500mg
• 50/1000mg

Cautions

• Lactic Acidosis: Lactic Acidosis, which is rare, but potentially life-threatening, may occur due to metformin use. Patients with kidney problems, liver problems, and alcoholism are at increased risk for developing Lactic Acidosis. Symptoms include muscle pain, weakness, and trouble breathing, and if left untreated, may lead to organ failure.
• Hypoglycemia: The combination of Vildagliptin and Metformin may cause low blood sugar (hypoglycemia), especially in patients who are taking insulin or other medications that lower blood sugar levels. Symptoms include sweating, shakiness, and confusion.
• Vitamin B12 Deficiency: Some studies have shown that long-term metformin use may lead to a deficiency in vitamin B12, which may cause anemia, nerve problems, and other health issues.
• Renal Impairment: If you have kidney problems, your doctor may need to adjust the dose of Galvus Met.
• Hepatic Impairment: If you have liver problems, your doctor may need to adjust the dose of Galvus Met.
• Pancreatitis: In rare cases, Vildagliptin has been associated with pancreatitis, a potentially life-threatening inflammation of the pancreas.
• Heart Failure: Patients with a history of heart failure may be more susceptible to fluid buildup in their body (edema) while using Galvus Met.
• Hypersensitivity: Galvus Met may cause an allergic reaction in some patients, especially those with a history of hypersensitivity to vildagliptin or metformin.
• Surgery: If you are scheduled to undergo surgery, you should inform your doctor or surgeon that you are taking Galvus Met, as it may increase the risk of complications during and after the procedure.
• Pregnancy and breastfeeding: The safety and effectiveness of Galvus Met during pregnancy and breastfeeding have not been fully established. Therefore, patients who are pregnant or breastfeeding should consult their doctor before using Galvus Met.
• Drug Interactions: Galvus Met may interact with other medications, including other diabetes medications, anticoagulants, and some antibiotics, among others. Therefore, inform your doctor or pharmacist of all the medications you are currently taking before starting treatment with Galvus Met.

Frequently Asked Questions (FAQ)

Can Galvus Met cause weight gain?

There is no strong evidence to suggest that Galvus Met causes significant weight gain. However, some patients may experience slight weight gain or weight loss as a side effect of Galvus Met.

Is Galvus Met safe for use in elderly patients?

Yes, Galvus Met is considered safe for use in elderly patients, although the dosage may need to be adjusted based on the patient's kidney and liver function.

Can Galvus Met be taken during fasting?

Galvus Met can be taken with or without food, depending on the patient's preference. However, if taken on an empty stomach, it may cause gastrointestinal side effects such as nausea and diarrhea.

Resources

• https://www.netmeds.com/prescriptions/galvus-met-50-1000mg-tablet-15-s
• https://www.practo.com/medicine-info/galvus-met-50-mg-1000-mg-tablet-45173
• https://www.1mg.com/drugs/galvus-met-50mg-1000mg-tablet-476049
• https://www.breathewellbeing.in/blog/galvus-met-50-500-mg-tablet-uses-side-effects-dosage-interactions/
• https://www.novartis.com/sg-en/sites/novartis_sg/files/Galvus_Met-Jul2020.SIN-App051120.pdf
• https://www.apollopharmacy.in/medicine/galvus-met-50-1000mg-tablet-15-s