Safely Buy Zofran ODT ( Ondansetron ) from Canada Prescriptions Plus.

Indications

Zofran ODT is an anti-nausea medicine used to prevent nausea and vomiting caused by chemotherapy and radiation therapy cancer medicines. The drug is also used to prevent nausea that may occur after receiving surgery.

Ondansetron is a selective serotonin receptor antagonist that inhibits specific receptor sites affected by cancer medications. By blocking the release of serotonin from these areas, Zofran ODT reduces your vomiting reflex and can help prevent nausea in response to treatment.

Dosage and Administration

The dose of Zofran ODT that is prescribed may vary depending on the individual being treated and the type of cancer treatment they are receiving. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best response during treatment. Do not take more or less than prescribed for a different length of time than directed by your healthcare provider.

• Do not chew or swallow Zofran ODT tablets
• Take with or without food, but your healthcare provider may instruct you to not eat before treatment or therapy
• Place tablets on your tongue and let them dissolve completely
• Swallow disintegrated tablets with your saliva
• Taking this tablet with water may increase your risk of getting a headache
• Dry your hands before handling tablets to avoid them from disintegrating in your hands
• If taken on a regular schedule, take at the same times each day for the best results
• Store at room temperature away from children and pets

Doses to prevent nausea from chemotherapy:

• Adults receiving highly emetogenic chemotherapy should take 24mg 30 minutes before treatment
• For moderately emetogenic chemotherapy, adults should take 8mg 30 minutes before followed by 8mg every 12 hours for 1 to 2 days following treatment
• Children aged 12 to 17 receiving moderately emetogenic chemotherapy should take 8mg 30 minutes before treatment

followed by 8mg taken 8 hours after the first dose and then every 12 hours for 1 to 2 days after completing chemotherapy

• Children aged 4 to 11 should take 4mg 30 minutes before treatment and then 4mg 8 hours later followed by 4mg three times a day for 1 to 2 days after chemotherapy.

To prevent nausea from radiation therapy:

• For total body irradiation treatment, take 8mg 1 to 2 hours before each fraction of treatment each day
• For single high-dose fraction treatment to your abdomen, take 8mg 1 to 2 hours before followed by 8mg every 8 hours for 1 to 2 days after treatment
• For fractioned abdominal radiotherapy given daily, take 8mg 1 to 2 hours before treatment followed by 8mg every 8 hours for each day treatment is given

To prevent nausea after surgery:

• Most adults take 16mg 1 hour before being given anesthesia

Side Effects

Zofran ODT may cause some side effects to develop while affecting your production of serotonin. Speak with your healthcare provider to learn more about any symptoms that you may have during treatment.

Common Zofran ODT side effects:

• Headache
• Light-headedness, dizziness
• Tiredness
• constipation

Serious Side Effects

Some more serious side effects may occur during treatment with Zofran ODT. Contact your healthcare provider right away if you develop any of the following symptoms:

• Stomach pain
• Muscle spasms or stiffness
• Blurred vision, temporary vision loss, or other vision changes
• Chest pain
• Irregular heartbeat or heart rate
• Severe dizziness
• Fainting

In rare occasions this medication may cause you to have high levels of serotonin and develop a condition called serotonin syndrome. Contact your healthcare provider right away if you notice any of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea, vomiting, diarrhea, twitching muscles, unexplained fever, unusual agitation, or restlessness)

Allergic Reactions

Do not take Zofran ODT if you are allergic to ondansetron or any of the other ingredients used in the disintegrating tablet. Stop using this medication and contact your healthcare provider if you develop any of the following signs of an allergic reaction:

• Rash
• Itching or swelling of face, lips, tongue, or throat
• Severe dizziness
• Trouble breathing

Cautions

• To ensure your safety when taking Zofran ODT, tell your healthcare provider if you have ever had any of the following conditions:
  • Irregular heartbeat
  • Liver disease
  • Stomach or intestinal problems including surgery or swelling
• Do not take Zofran ODT if you are also receiving apomorphine.
• Zofran ODT may cause an increase in the prolongation of your QT interval which can lead to fast heart rates and fainting. Your risk of developing QT prolongation may be increased if you have certain heart problems or a family history of the same conditions.
• Avoid drinking alcohol during treatment with Zofran ODT because it can cause an increase in adverse reactions.
• Do not drive or perform hazardous tasks that require alertness until you know how this medication will affect you. Zofran ODT can cause you to become dizzy or drowsy which impairs your reactions.
• If you have phenylketonuria or any other condition that requires you to avoid aspartame, consult with your healthcare provider about the use of Zofran because it may contain aspartame.
• Tell your healthcare provider if you are pregnant or plan to become pregnant during treatment because Zofran may cause harm to your unborn baby if taken during pregnancy.
• Consult with your healthcare provider before breastfeeding while taking Zofran ODT because it is unclear if it passes into breastmilk.
• Some drugs may interact with Zofran ODT and cause unwanted affects. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
  • Apomorphine
  • Tramadol
  • Serotonergic drugs including selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors
  • Phenytoin, carbamazepine, rifampin

Form and Strength

This anti-nausea cancer medicine is available in the form of orally disintegrating tablets.

• Zofran ODT tablet strengths:
  • 4mg
  • 8mg

Zofran ODT tablet strengths are both available in quantities of 10.

FAQ

Can I drink water after taking ODT Zofran?

You can drink water, but do not take your Zofran tablet with water. Let the tablet dissolve on your tongue and swallow it with saliva. Once you have taken all the medication, you can drink water. If you drink too soon after you may be more likely to develop headaches.

What not to do after taking Zofran?

After taking your dose of Zofran ODT, you should avoid drinking alcohol because it can cause you to become nauseous or experience an increase in possible side effects including dizziness and drowsiness. You should also avoid driving or performing hazardous activities if the medication causes you to become drowsy or dizzy. Follow all your healthcare provider’s instructions for use for the best results.

Resources:

1. https://www.drugs.com/cons/zofran-odt.html
2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=92c758a3-e749-4a15-be4b-ee30b364b2b0&type=display
3. https://www.healthlinkbc.ca/medications/ondansetron-disintegrating-tablet-oral