Safely Buy Tarka ( Trandolapril/Verapamil ) from Canada Prescriptions Plus.

Indications

Tarka is a blood pressure medication used to treat hypertension (high blood pressure) and reduce the risk of strokes and heart attacks.

This antihypertensive medicine combines trandolapril, an angiotensin-converting enzyme (ACE) inhibitor, with verapamil, a calcium channel blocker (CCB). Together these drugs lower sitting systolic and diastolic blood pressure thanks to their inhibitory actions.

Combining two antihypertensive agents makes Tarka an effective treatment for high blood pressure in those who don’t respond to monotherapies and who are at higher risk of developing a stroke or heart attack. This medication provides 24-hour ambulatory blood pressure control better than if trandolapril or verapamil were used separately without a major increase in adverse effects.

Uses and Dosage

The dose of Tarka that is prescribed will vary depending on the individual and the severity of their condition being treated. Follow your doctor’s instructions and read packaging labels carefully to ensure the best therapeutic results.

• Swallow tablets whole
• Take with food at the same time each day
• Most adults take 1 to 4mg of trandolapril and 180 to 240mg of verapamil daily
• Doses may be taken once or twice each day
• Continue taking Tarka daily as directed, even if you feel well
• Store at room temperature away from moisture and heat
• Keep away from children and pets

Side Effects

Tarka may cause some side effects to occur while lowering your blood pressure levels. Speak with your doctor for more specific information relating to any symptoms that you may encounter when taking trandolapril and verapamil.

Common Tarka side effects:

• Cough
• Cold symptoms (stuffy nose, sneezing, sore throat)
• Headache, dizziness
• Chest pain, back pain
• Constipation
• Tiredness
• Abnormal liver function tests

Serious Side Effects

Some more serious adverse reactions may occur when taking trandolapril and verapamil. Stop using Tarka and call your doctor right away if you develop any of the following side effects:

• Light-headed feeling like you might pass out
• Upper stomach pain, jaundice
• Chest pain
• Fast, slow, or uneven heart rate
• High potassium levels (nausea, weakness, tingling, chest pain, irregular heartbeats, loss of movement)
• Kidney problems (little or no urination, swelling in feet or ankles, tiredness, shortness of breath)
• Low white blood cell counts (fever, chills, light-headedness, mouth sores, skin sores, sore throat, cough, trouble breathing)
• Fluid build-up in or around your lungs (pain when breathing, shortness of breath while laying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats)

Allergic Reactions

Do not use Tarka if you are allergic to trandolapril or verapamil or to any other ACE inhibitor. If you develop signs of an allergic reaction, stop taking this medication and contact your doctor.

Tarka allergy symptoms may include:

• Hives, rash
• Itching
• hoarseness
• Difficulty breathing or swallowing
• Swelling of the face, lips, tongue, or throat

Cautions

Tarka is designed to be used after monotherapy failed to provide effective treatment for your hypertension.

Tarka may cause your condition to worsen if you have heart disease or heart rhythm problems. See your doctor right away if you develop chest pain or tightness, decreased urination, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet or legs, trouble breathing, or weight gain.

Do not take potassium supplements or salt substitutes when taking Tarka unless directed to do so by your doctor.

Do not use Tarka if you have any of the following:

• Certain serious heart conditions like sick sinus syndrome or AV block if you don’t have a pacemaker
• Heart rhythm disorder
• Low blood pressure

Move slowly when standing from a lying or sitting position to avoid getting dizzy or lightheaded.

Avoid smoking while taking Tarka because it can impact the efficacy of the drug.

Avoid drinking alcohol and grapefruit juice because both can interact with Tarka and cause unwanted side effects.

To ensure your safety when taking Tarka, tell your doctor if you have any of the following:

• Kidney or liver disease
• Congestive heart failure
• Diabetes
• Nerve-muscle disease such as muscular dystrophy

Some drugs may interact with trandolapril or verapamil and cause unwanted reactions. To avoid this, tell your doctor about all the medications that you take, including over the counter medicines, but especially any of the following:

• Cytochrome P450 system inhibitors or inducers (erythromycin, ritonavir, rifampin)
• Lithium
• Clarithromycin
• Erythromycin
• Cimetidine
• Carbamazepine
• Antiarrhythmic agents
• Other antihypertensive agents
• Beta-adrenergic blockers
• Diuretic medicines
• Statin medications
• Non-steroidal anti-inflammatory agents
• Immunosuppressive agents
• Sedatives
• Antidepressants
• Insulin or oral diabetes medication

Do not take Tarka with any medication containing aliskiren if you also have diabetes.

Do not take Tarka within 2 weeks before or 2 days after using flibanserin to avoid serious adverse effects.

Do not use Tarka within 36 hours of sacubitril/valsartan.

If you are pregnant, do not use Tarka because it can cause harm to your unborn child. Use effective birth control methods to avoid getting pregnant during treatment.

Do not breastfeed while taking Tarka because it can pass into your breast milk and may cause harm to your child.

Form and Strength

This antihypertensive medication is available in tablet form.

Tarka tablet strengths:

• 2mg trandolapril / 180mg verapamil
• 2/240mg

The 2/180mg strength Tarka tablets are available in quantities of 84 while the 2/240mg ones are available in quantities of 100.

FAQ

When is the best time to take Tarka?

Tarka should be taken with food or right after eating at the same time each day. Your doctor may recommend taking your dose in the morning to help with absorption. If you take an antacid medication, wait at least 2 hours before or after your Tarka dose to not impede its absorption.

How does Tarka work?

Tarka is an antihypertensive medication that combines the ACE inhibitor trandolapril with the calcium channel blocker verapamil to help lower and control your blood pressure. The medication does this thanks to the inhibitory effects of either drug or is more effective than either one used alone.

Resources:

1. https://pubmed.ncbi.nlm.nih.gov/12421112/
2. https://pubmed.ncbi.nlm.nih.gov/17583177/
3. https://pubmed.ncbi.nlm.nih.gov/10855738/
4. https://www.drugs.com/mtm/tarka.html
5. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b4b1dd5-8a6f-4f0e-a2ea-506c60d6fce9