Safely Buy Kombiglyze XR ( Metformin/Saxagliptin ) from Canada Prescriptions Plus.

Indications

Kombiglyze XR is a medication used to improve glycemic control in adults with type 2 diabetes mellitus.

Kombiglyze Xr is an oral combination of two antihyperglycemic medications, saxagliptin, and metformin.

The medication is taken in conjunction with a proper diet and exercise program to help control high blood sugar levels.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start using saxagliptin/metformin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once a day with the evening meal.

Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release the entire drug at once, increasing the risk of side effects.

Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, peeling skin; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Some people using metformin develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:

• Unusual muscle pain
• Feeling cold
• Trouble breathing
• Feeling dizzy, light-headed, tired, or very weak
• Stomach pain or vomiting
• Irregular heart rate

Call your doctor at once if you have any of these serious side effects:

• Severe autoimmune reaction–itching, blisters, or breakdown of the outer layer of skin
• Severe or ongoing pain in your joints
• Pain or burning when you urinate
• Symptoms of heart failure–shortness of breath (even while lying down), swelling in your legs or feet, or rapid weight gain

Common side effects of metformin and saxagliptin may include:

• Diarrhea or nausea
• Headache
• Cold symptoms such as runny or stuffy nose, sneezing, or sore throat

This is not a complete list of side effects and others may occur.

Cautions

• Before taking this medication, tell your doctor or pharmacist if you are allergic to saxagliptin or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), liver disease, disease of the pancreas (pancreatitis), risk factors for pancreatitis (such as stones in your gallbladder, regular use/abuse of alcohol, high levels of fats/triglycerides in the blood).
• Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.
• You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
• Limit alcohol while taking this medication because it can increase your risk of developing lactic acidosis, pancreatitis, and low blood sugar.
• High fever, “water pills” (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause dehydration and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.
• It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.
• Older adults may be more sensitive to the side effects of this drug, especially low blood sugar or lactic acidosis.
• Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the chance of pregnancy. Consult your doctor or pharmacist about using reliable birth control while taking this medication.
• During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
• Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).
• Metformin passes into breast milk in small amounts. It is unknown if saxagliptin passes into breast milk. Consult your doctor before breast-feeding.

Form and Strengths

Kombiglyze XR is available in the following forms and strengths:

• Kombiglyze XR Tablet:
  • 5/500 mg
  • 5/1000 mg
  • 2.5/ 1000 mg

FAQ

What happens if I miss a dose?

Take the medicine (with food) as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention. You may have severely low blood sugar (extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizures).

What should I avoid while taking metformin and saxagliptin?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

Resources:

1. https://www.webmd.com/drugs/2/drug-154922/kombiglyze-xr-oral/details
2. https://www.drugs.com/mtm/metformin-and-saxagliptin.html#side-effects
3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fbd25da4-ebe6-45c9-beb8-93523d11a0b4