Safely Buy Zoladex ( Goserelin ) from Canada Prescriptions Plus.

Indications

Zoladex (goserelin) is a medication used for hormone therapy to treat breast cancer and prostate cancer, as well as certain benign gynecological disorders such as endometriosis.

Zoladex is an analog of a hormone called luteinizing hormone-releasing hormone (LHRH), which works by overstimulating the body’s production of LHRH, leading to a decrease in testosterone production in men and estrogen production in women.

Use and Dosage

Usual Adult Dose for Prostate Cancer:

For the palliative treatment of advanced carcinoma of the prostate:

3.6 mg or 10.8 mg subcutaneously into the upper abdominal wall once, the 3.6 mg dosage may be repeated every 28 days. The 10.8 mg dosage may be repeated every 12 weeks.

Intended for long-term administration unless clinically inappropriate.

Prostate cancer, stage B2 to C (in combination with an antiandrogen and radiotherapy; begin 8 weeks before radiotherapy): Males: SubQ: Combination 28-day/12-week implant: 3.6 mg implant, followed in 28 days by 10.8 mg implant OR 28-day implant (alternate dosing): 3.6 mg; repeated every 28 days for a total of 4 doses (2 depots preceding and 2 during radiotherapy)

Uses:

• In combination with flutamide for the management of locally confined Stage T2b-T4 (Stage B2-C) carcinoma of the prostate. Treatment should start 8 weeks before radiation therapy and continue during radiation.
• For the palliative treatment of advanced carcinoma of the prostate.

Usual Adult Dose for Endometriosis:

3.6 mg subcutaneously into the upper abdominal wall once; repeat every 28 days

The recommended duration of therapy is 6 months.

Use: For the management of endometriosis, including pain relief and reduction of endometriotic lesions.

Usual Adult Dose for Breast Cancer–Palliative:

For use in the palliative treatment of advanced breast cancer: 3.6 mg subcutaneously into the upper abdominal wall once; repeat every 28 days

Intended for long-term administration unless clinically inappropriate.

Use: For the palliative treatment of advanced breast cancer in pre-and perimenopausal women

Usual Adult Dose for Bleeding:

1 or 2 of the 3.6 mg subcutaneous depot injections (with each depot given 4 weeks apart). When 1 depot is administered, surgery should be performed at 4 weeks. When 2 depots are administered, surgery should be done within 2 to 4 weeks after the second depot’s administration.

Use: For use as an endometrial-thinning agent before endometrial ablation for dysfunctional uterine bleeding.

Side Effects

Serious side effects include:

• Hives
• Difficulty breathing
• Swelling of your face, lips, tongue, or throat
• Painful or difficult urination
• Pain, bruising, swelling, redness, oozing, or bleeding where the implant was injected
• Increased thirst
• Increased urination
• Hunger
• Dry mouth
• Fruity breath odor
• Drowsiness
• Dry skin
• Blurred vision
• Weight loss
• Nausea
• Vomiting
• Constipation
• Increased thirst or urination
• Muscle pain
• Weakness
• Bone pain
• Confusion
• Tiredness
• Restlessness
• Chest pain or pressure
• Pain spreading to your jaw or shoulder
• Sweating
• Back pain
• Muscle weakness
• Problems with balance or coordination
• Severe numbness or tingling in your legs or feet
• Loss of bladder or bowel control
• Sudden numbness or weakness (especially on one side of the body)
• Sudden severe headache
• Slurred speech
• Problems with vision or balance

Get medical help right away if you have any of the symptoms listed above.

Common side effects include:

• Hot flashes (flushing)
• Dizziness
• Headache
• Increased sweating
• Increased or decreased sexual interest
• Impotence
• Fewer erections than usual
• Trouble sleeping
• Nausea
• Change in breast size
• Breast swelling or tenderness
• Vaginal dryness/itching/discharge
• Hair loss, mental/mood changes (such as depression, mood swings, hallucinations)
• Injection site reactions (pain, bruising, bleeding, redness, or swelling)
• Bone pain
• Diarrhea
• Constipation
• Sleep problems (insomnia)
• Acne
• Skin rash or itching

Cautions

You should not be treated with Zoladex implants if you are allergic to goserelin, or to similar hormone medications such as histrelin, leuprolide, nafarelin, or ganirelix.

This medicine can harm an unborn baby, but goserelin is sometimes used in pregnant women with advanced breast cancer. Unless you are being treated for advanced breast cancer, you should not use Zoladex during pregnancy. You may need to have a negative pregnancy test before starting this treatment.

If you have not gone through menopause, you should use a nonhormonal form of birth control (condom, diaphragm, cervical cap, contraceptive sponge) to prevent pregnancy while the Zoladex implant is in place.

Keep using birth control for at least 12 weeks after the implant was removed. Even though the Zoladex implant can stop ovulation and menstrual periods, you could still become pregnant.

To make sure Zoladex is safe for you, tell your doctor if you have ever had:

• Diabetes
• Heart problems, heart attack, or stroke
• Bone cancer
• Long QT syndrome (in you or a family member)
• Low bone mineral density (osteoporosis)
• Abnormal vaginal bleeding that has not been checked by a doctor

Form and Strengths

Zoladex is available in the following form and strengths:

Zoladex Disposable Syringe:

• 3.6 mg

FAQ

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment to receive your Zoladex implant.

What happens if I overdose?

Since the Zoladex implant contains a specific amount of the medicine, you are not likely to receive an overdose.

What to avoid?

Avoid drinking alcohol. It can increase your risk of bone loss while you are being treated with Zoladex. Avoid smoking, which can increase your risk of bone loss, stroke, or heart problems.

Resources:

1. https://www.drugs.com/zoladex.html#before-taking
2. https://www.rxlist.com/zoladex-drug.htm
3. https://www.zoladex.com/