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Indications

Norvasc is a blood pressure medication used to treat chest pain (angina), high blood pressure, and other conditions in those with coronary artery disease.

Amlodipine is a dihydropyridine calcium antagonist that binds to specific receptor sites to offer sustained antihypertensive effects by inhibiting the conversion of calcium ions into vascular smooth muscle and cardiac muscle. Norvasc acts within cell membranes and helps reduce peripheral vascular resistance and blood pressure.

This calcium channel blocker has a slow onset of action and long duration that offers a lower incidence of adverse vasodilator effects compared to other similar drugs. Thanks to its long elimination half-life, Norvasc can be taken once a day while providing effective relief from symptoms.

Uses and Dosage

The dose of Norvasc prescribed will vary depending on the individual and vascular condition being treated. Follow all your doctor’s directives and read packaging labels carefully when taking any medication.

  • Swallow tablets whole
  • Take with or without food at the same time each day
  • Most adults take an initial dose of 5mg once daily
  • Those with lower tolerance may start with 2.5mg once daily
  • Doses can be titrated up to no more than 10mg once daily after 7 or 14 days
  • For angina and coronary artery disease, adults are recommended to take 10mg once daily
  • Children aged 6 to 17 usually take between 2.5 and 5mg once daily
  • Your blood pressure will need to be checked regularly during treatment
  • For hypertensive treatment, keep using Norvasc even if you feel well
  • Norvasc is prescribed in combination with a program of diet, exercise, and other medications
  • Store at room temperature away from moisture, heat, and light
  • Store out of reach of children

Side Effects

Norvasc may cause some side effects to develop while it reduces your blood pressure and symptoms associated with coronary artery disease. Speak with your doctor for more information regarding symptoms you may encounter when taking amlodipine.

Common Norvasc side effects:

  • Dizziness, drowsiness
  • Tiredness
  • Stomach pain, nausea
  • Flushing (warmth, redness, or tingling)
  • Swelling in ankles and lower legs

Serious Side Effects

Some more serious adverse effects may occur when taking amlodipine. Stop using Norvasc and call your doctor immediately if you notice any of the following side effects:

  • Pounding heartbeats or fluttering in your chest
  • Worsening chest pain
  • Swelling in your feet or ankles
  • Severe drowsiness
  • Lightheaded feeling like you might pass out

Allergic Reactions

Do not take Norvasc if you are allergic to amlodipine. If you show symptoms of an allergic reaction, stop taking this medication and contact your doctor.

Norvasc allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat

Cautions

Tell your doctor if you have congestive heart failure or liver disease before taking Norvasc to ensure your safety.

Do not drink alcohol while taking Norvasc; it can lower your blood pressure further and increase the drug’s adverse effects.

Continue taking your Norvasc doses if they are being used to treat high blood pressure even if you feel well. Hypertension often has no symptoms, and it is important to maintain your blood pressure levels.

Your chest pain may worsen when you first start taking this medicine or if your dose is increased. Contact your doctor if you experience chest pain that is severe or ongoing.

Tell your doctor if you have ever had aortic stenosis, a heart valve problem, to ensure Norvasc is safe for you to take.

Some drugs can interact with amlodipine and cause adverse reactions. Tell your doctor about all the medications you take, including over the counter medicine, vitamins, and herbal products, but especially any of the following:

  • Nitroglycerin
  • Simvastatin
  • Any other heart or blood pressure medications

To avoid feeling dizzy and prevent falls, move slowly when standing from a seated or lying position.

Tell your doctor if you are pregnant or plan to become pregnant while taking Norvasc. Amlodipine’s effects on unborn babies are unknown but having high blood pressure during pregnancy can cause serious complications for both mother and baby.

Amlodipine can pass into breastmilk but the effects it has on nursing babies is unknown. Consult your doctor before breastfeeding while taking Norvasc.

Norvasc is not an approved treatment for anyone under the age of 6 years old.

Form and Strength

This blood pressure medication is available in tablet form.

Norvasc tablet strengths:

  • 2.5mg
  • 5mg
  • 10mg

The 2.5mg Norvasc tablets are available in quantities of 30 or 90 while the 5 and 10mg tablets are both available in quantities of 28, 84, or 90.

FAQ

What is the best time of day to take blood pressure medication?

Studies have found that taking blood pressure medication such as Norvasc at night offers better control of your blood pressure during the night without diminishing daytime effects. This is especially true for this medication thanks to amlodipine’s long duration and slow elimination half-life because it stays active in your system for longer.

Does Norvasc cause weight gain?

Some patients taking Norvasc have reported fluctuations in their weight, including weight gain, but this is not a common side effect of amlodipine. Other patients have even reported weight loss when using this medication. Consult with your doctor for more information if you are worried about changes in your weight while using this medication.

Resources:

  1. https://pubmed.ncbi.nlm.nih.gov/9156957/
  2. https://pubmed.ncbi.nlm.nih.gov/1834846/
  3. https://pubmed.ncbi.nlm.nih.gov/31345001/
  4. https://www.drugs.com/norvasc.html
  5. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abd6a2ca-40c2-485c-bc53-db1c652505ed

Additional information

Brand Name:

Norvasc

Scientific Name:

Amlodipine

Other Names:

Amlodipine, Amlogard, Amlopres, Norvasc

Strength(s):

2.5mg, 5mg, 10mg

Quantities Available:

28, 30, 56, 84, 90

Formulation:

Tablet