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Formulation : Extended Release Tablet
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Indications

Mirapex ER is a prescription medication that contains pramipexole dihydrochloride and is primarily used to treat the signs and symptoms of Parkinson’s disease.

Mirapex ER can help improve movement abilities and decrease symptoms such as tremors, muscle spasms, stiffness, and poor muscle control associated with Parkinson’s disease.

Use and Dosage

Read the Patient Information Leaflet provided by your pharmacist before you start taking pramipexole and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Swallow this medication whole. Do not crush, chew, or break the tablets. Doing so can release the entire drug at once, increasing the risk of side effects. Take this medication by mouth with or without food as directed by your doctor, usually once daily. Taking this medication with food may lessen nausea. To reduce your risk of side effects (such as drowsiness, and low blood pressure), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or take it more often than directed.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this medication is suddenly stopped. Also, if you suddenly stop using this medication, you may have withdrawal symptoms (such as anxiety, depression, confusion, fever, muscle stiffness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used pramipexole for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

If you temporarily stop taking this medication, you may need to start this medication again at a low dose and gradually increase your dose. Talk with your doctor about how to restart this medication.

It may take a few weeks for the effects of this medication to be noticed. Tell your doctor if your condition does not get better or if it gets worse.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some people taking Mirapex ER have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

Serious side effects include:

  • A light-headed feeling, like you might pass out
  • Hallucinations (seeing or hearing things that are not real)
  • Extreme drowsiness, falling asleep suddenly, or even after feeling alert
  • Tremors, twitching, or uncontrollable muscle movements
  • Unexplained muscle pain, tenderness, or weakness
  • Vision problems
  • Posture changes you cannot control, such as involuntary bending forward of your neck, bending forward at the waist, or tilting sideways when you sit, stand, or walk

Side effects such as confusion or hallucinations may be more likely in older adults.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking Mirapex ER. Talk with your doctor if this occurs.

Common side effects of Mirapex ER may include:

  • Muscle spasm or muscle weakness
  • Drowsiness, dizziness, or weakness
  • Confusion or memory problems
  • Dry mouth
  • Nausea or constipation
  • Increased urination
  • Sleep problems (insomnia) or unusual dreams

This is not a complete list of side effects and others may occur.

Cautions

  • Before taking pramipexole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure, heart problems (such as irregular heartbeat, heart failure), kidney problems, mental/mood disorders (such as confusion, hallucinations, psychosis, schizophrenia), sleep disorder (such as sleep apnea, narcolepsy).
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • Older adults may be at a greater risk for dizziness and hallucinations while using this drug.
  • This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). See also the Side Effects section.
  • During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
  • This drug may pass into breast milk and could have undesirable effects on a nursing infant. It may also affect milk production. Breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.

Forms and Strengths

Mirapex ER is available in the following forms and strengths:

  • Mirapex ER Tablet:
    • 0.375 mg
    • 0.75 mg
    • 1.5 mg
    • 3 mg
    • 3.75 mg
    • 4.5 mg
  • Pramipexole ER Tablet:
    • 0.375 mg
    • 0.75 mg
    • 1.5 mg
    • 3 mg

FAQ

What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while taking Mirapex ER?

Do not drink alcohol. Dangerous side effects can occur when alcohol is combined with Mirapex ER.

Avoid driving or hazardous activity until you know how Mirapex ER will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Resources:

  1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2902ed1-cfeb-4815-adc3-129c577917a1
  2. https://www.drugs.com/mtm/mirapex-er.html#side-effects
  3. https://www.webmd.com/drugs/2/drug-153659/mirapex-er-oral/details

Additional information

Brand Name:

Mirapex ER

Scientific Name:

Pramipexole

Other Names:

Pexola ER, Pramipex ER, Pramipexole PR, Sifrol ER

Strength(s):

0.75mg, 0.375mg, 1.5mg, 3.75mg, 3mg, 4.5mg

Quantities Available:

30, 90, 100, 180

Formulation:

Extended Release Tablet