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What Is Xarelto (Rivaroxaban)?

Xarelto medication is indicated to treat and prevent blood clots, which can be fatal. This medication belongs to a class of medicines known as blood thinners (also called anticoagulants). Xarelto’s generic name is Rivaroxaban.

Xarelto (Rivaroxaban) is used to treat the following conditions in adults:

  • Lowers the risk of stroke and blood clots with AFib, not caused by heart valve problems.
  • Treats deep vein thrombosis (DVT or blood clots in the legs) and pulmonary embolism (PE or blood clots in the lungs).
  • Decreases the recurrence of DVT and PE after receiving treatment for at least six months.
  • Prevents blood clots following hip or knee replacement surgery, being hospitalized with acute illness, and those who are at high risk for clot formation.
  • Reduces the risk of heart-related problems in people with coronary artery disease (CAD).
  • Lowers the risk of circulatory problems and complications in patients with peripheral artery disease (PAD).

Meanwhile, this medication is also used for treating children with the following conditions:

  • Treats venous thromboembolism (VTE) and reduces recurrence of VTE after receiving at least five days of treatment with injectable blood thinners in children from birth to <18 years.
  • Prevents blood clot formation in individuals two years old and above with congenital heart disease after the Fontan procedure.

How to Use Xarelto (Rivaroxaban)

The Xarelto dosage must be individualized according to the needs of the patient. It is typically based on the severity of the client’s existing health problem, any coexisting illnesses, and how they respond to the regimen.

When using this anticoagulant, read all prescription information and follow all the directions carefully. If you are unsure about how to use this oral medication, talk to your doctor or pharmacist for clarification.

The following are the Xarelto uses and recommended dosages:

  • The typical dosage of Xarelto to decrease the risk of stroke and blood clots in patients with AFib is 20 mg once a day with food.
  • The initial dose to treat DVT and PE is 15 mg twice daily for 21 days and 20 mg once a day with food at the same time each day.
  • The suggested intake to prevent the recurrence of DVT and PE is to take 10 mg once daily with food after at least six months of standard anticoagulant therapy.
  • The usual dose to prevent blood clots following hip or knee replacement surgery is 10 mg once daily, with or without food, six to ten hours after the procedure. This medication is used for 12 days for knee replacement surgery and 35 days for hip replacement surgery.
  • For the prevention of VTE, the recommended daily intake is 10 mg starting in the hospital and continuing after discharge for a total of 31 to 39 days with or without food.
  • The usual dose to decrease the risk of heart-related problems in patients with CAD and PAD is 2.5 mg two times a day, plus aspirin (75 to 100 mg) once daily with or without food.

For children:

  • The Xarelto dose for children is based on their weight, usually given one to three times a day, as prescribed.

The following are the directions for administering Rivaroxaban:

  • Administer this film-coated tablet depending on your condition or as prescribed by your doctor. Take the Xarelto tablet whole with a full glass of water.
  • Splitting this medication is not recommended. However, if you have difficulty swallowing the pill whole, you may crush and mix the tablets with applesauce.

The effects of this anticoagulant medication depend on how your body responds to it. Usually, it starts to work after two to four hours following administration and leaves the system more quickly than warfarin, typically within 24 hours.

Side Effects Of Xarelto (Rivaroxaban)

Rivaroxaban may have unwanted side effects similar to other medications that may resolve over time when your body has adjusted to the medicine.

The following are the common side effects of this anticoagulant that can develop when taking this pill:

  • Bleeding
  • Cough
  • Vomiting
  • Gastroenteritis (infection and inflammation of the gastrointestinal system)

Serious Side Effects

  • Increased risk of blood clots if you stop using this medication.
  • Increased bleeding risk
    • Bruise easily
    • Prolonged bleeding
  • Spinal or epidural blood clots

Allergic Reactions

  • Skin rash
  • Itching
  • Chest pain
  • Swelling (face/tongue/throat)
  • Trouble breathing
  • Dizziness

Fatigue or lack of energy was noted in patients taking this medication. Also, weight changes are not reported as side effects of this medication.

Note that this list does not include all the medical information and health implications related to Xarelto’s side effects.

Xarelto (Rivaroxaban) Precaution

When using Xarelto medication, make sure to be cautious when doing the following:

  • Abrupt discontinuation as this can increase your risk of blood clots and bleeding.
  • Receiving anticoagulants and spinal medications or procedures can raise your risk for spinal or epidural hematoma.

Before using this anticoagulant medication, make sure to fully disclose your medical history to your doctor, especially if you have the following, as this will help them determine if this is safe for you:

  • Liver or kidney problems
  • Bleeding disorders
  • Antiphospholipid syndrome (APS)
  • Pregnant or trying to get pregnant
  • Breastfeeding

Do not take this medication if you are allergic to Rivaroxaban and other active components. Also, avoid using this tablet if you have:

  • Abnormal bleeding
  • Artificial heart valves
  • Antiphospholipid syndrome (APS), especially with positive triple antibody testing

Do not take this medication if you are allergic to rivaroxaban and any of its inactive ingredients. Also, avoid using this medication if you have abnormal bleeding or artificial heart valves.

Inform your doctor if you are using other medicines that can increase your risk of bleeding and affect the mechanism of action of Rivaroxaban:

  • Ketoconazole
  • Erythromycin
  • Carbamazepine
  • Phenytoin
  • Rifampin
  • St. John’s wort
  • Ritonavir
  • Long-term use of NSAIDs
  • Medicines containing aspirin

Spinal procedures can cause blood clots, which can cause permanent or long-term paralysis. Be vigilant for symptoms of spinal cord injury, including backache, numbness, weakness, or loss of bowel or bladder control.

If you will undergo surgery, tell your surgeon that you are taking this medicine. This anticoagulant may be discontinued at least 24 hours before surgery to prevent excessive bleeding.

This medication should only be administered to pregnant women if the possible advantages outweigh the risks to the mother and fetus.

There is no known interaction between this medication and drinking caffeine or alcohol. However, make sure to contact your doctor if how much caffeine and alcohol are safe for you.

Keep Rivaroxaban tablets out of reach of the children and store them safely to preserve their effectiveness.

Xarelto (Rivaroxaban) Form and Strength

This medicine is available in tablet formulation with the following strengths:

  • Xarelto
    • 2.5 mg film-coated tablet
    • 10 mg film-coated tablet
    • 15 mg film-coated tablet
    • 20 mg film-coated tablet
  • Xarelto generic (Rivaroxaban)
    • 15 mg tablet
    • 20 mg tablet

FAQ

Is Xarelto a blood thinner?

Yes, this medication belongs to a class of medicines known as blood thinners (also known as anticoagulants).

Is Xarelto an anticoagulant?

Yes, this medication belongs to a class of medicines known as blood thinners (also known as anticoagulants).

References

2023. Xarelto- Rivaroxaban Tablet, Film Coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=10db92f9-2300-4a80-836b-673e1ae91610

2022. Answering Your AFib Questions. https://www.xarelto-us.com/atrial-fibrillation/afib-questions#:~:text=How%20long%20does%20XARELTO%C2%AE,typically%20in%20about%2024%20hours.

2022. Xarelto (Rivaroxaban) Tablets for Oral Use. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/022406Orig1s039,202439Orig1s038correctedlbl.pdf

2023. Xarelto Medication Guide. https://www.janssenlabels.com/package-insert/product-patient-information/XARELTO-medication-guide.pdf

Additional information

Brand Name:

Xarelto

Scientific Name:

Rivaroxaban

Other Names:

Rivaroxaban, Xarelto

Strength(s):

2.5mg, 10mg, 15mg, 20mg

Quantities Available:

10, 28, 30, 56, 84, 90, 100

Formulation:

Film Coated Tablet, Tablet

MedicationsCanada.com receives the above information for Xarelto (Rivaroxaban) from third parties. We provide this information for general informational purposes only, and it is not intended to replace the advice of a physician. Any medical concerns should always be discussed with your doctor or a qualified health care professional.