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Formulation : Nasal Spray
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Indications

Zomig nasal spray is an antimigraine medicine used to treat migraine headaches in adults and children over 12 years of age.

Zolmitriptan is a triptan medication that inhibits serotonin receptors to narrow the blood vessels in your brain. The drug may also affect neuropeptides that cause inflammation and reduce pain by affecting nerves in your brain. These actions all help Zomig nasal spray treat migraine headaches and related symptoms such as nausea and vomiting.

Dosage and Administration

The dose and administration regimen of Zomig nasal spray that is prescribed will vary depending on the individual being treated. Listen to all directions given by your healthcare provider and read packaging labels carefully to ensure the best therapeutic response from treatment. Do not change your dose or use this medication more often than prescribed.

  • Use this spray as soon as you notice migraine symptoms
  • Most patients take 2.5mg once or twice to treat migraine symptoms
  • Doses can increase if needed and tolerated
  • Adults and children over 12 should not use more than 5mg in one dose or take more than 10mg within 24 hours
  • To use this medication, gently blow your nose before administration
  • Remove the cap, block one of your nostrils, and place the spray tip into your free nostril
  • Breathe in while you press the nasal spray plunger
  • Remove the tip from your nose and slightly tilt back your head, breathing from your mouth for 5 to 10 seconds
  • If your symptoms are only partially relieved or if your migraine returns, use the spray again 2 hours following your first dose
  • Store at room temperature away from children and pets

Side Effects

Zomig nasal spray may cause some side effects to develop while affecting the chemicals and blood vessels in your brain. Talk to your healthcare provider for more information regarding any symptoms that you may encounter during treatment.

Common Zomig nasal spray side effects:

  • Pain or tightness in your throat or chest
  • Dry mouth, upset stomach
  • Pressure or heaviness in your body
  • Drowsiness, tiredness
  • flushing

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Zomig nasal spray. Stop using this medication and contact your healthcare provider if you develop any of the following side effects:

  • Tightness in your jaw, neck, throat, or chest
  • Blue fingers, toes, or nails
  • Cold hands or feet
  • Fast or pounding heartbeats
  • Dizziness
  • Sudden or severe stomach pain with bloody diarrhea
  • Heart attack symptoms (chest pain or pressure spreading to your jaw or shoulder, nausea, sweating)
  • High serotonin levels (agitation, hallucinations, fever, fast heartbeat, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting)

Allergic Reactions

Do not take Zomig nasal spray if you are allergic to zolmitriptan or any other triptan medications. Stop taking this medication and contact your healthcare provider if you notice any of the following signs of an allergic reaction:

  • Hives
  • Trouble breathing
  • Severe dizziness
  • Swelling face, lips, tongue, or throat

Cautions

  • Do not take Zomig nasal spray if you have any of the following conditions:
    • Coronary heart disease, angina
    • Lack of blood supply to your heart
    • History of heart disease, heart attack, or stroke
    • Wolff-Parkinson-White syndrome
    • Severe or uncontrolled high blood pressure
    • Blood vessel disorder or circulation problems
  • Do not use this nasal spray within 24 hours of taking a monoamine oxidase inhibitor (MAOI) including isocarboxazid, linezolid, and methylene blue injection.
  • To ensure your safety during treatment with Zomig nasal spray, tell your healthcare provider if you have ever had any of the following:
    • Problems with your blood circulation
    • Certain types of headaches like hemiplegic or basilar migraine
    • Heart problems
    • Liver disease
    • Seizure
    • Stroke
    • High blood pressure or cholesterol
    • Diabetes
  • Be careful when driving or performing hazardous activities, especially until you know how this medication will affect you. Zomig may cause you to become dizzy or drowsy which can impair your reactions.
  • Do not use this Zomig nasal spray within 24 hours of any other migraine medication including an oral form of Zomig, almotriptan, eletriptan, naratriptan, or ergot medicines like dihydroergotamine or ergotamine.
  • Tell your healthcare provider if you are pregnant to discuss the safety of using this medication while pregnant.
  • Ask your healthcare provider before breastfeeding while using Zomig nasal spray.
  • Some types of medications may interact with Zomig and cause unwanted side effects. Tell your healthcare provider about all the medications you take, but especially any of the following:
    • Antidepressant medications
    • Antipsychotic medicines
    • Narcotic medication
    • Medicine used to prevent nausea and vomiting
    • Cimetidine
  • Zomig nasal spray is not an approved treatment for any child under the age of 12.

Form and Strength

This antimigraine medicine is available in nasal spray form.

  • Zomig nasal spray strengths:
    • 2.5mg
    • 5mg

The 2.5mg strength Zomig nasal spray is available equipped with 6 doses while the 5mg strength nasal spray is available equipped with 6, 7, 21, or 28 doses.

FAQ

How often can you use Zomig spray?

You can use Zomig up to 2 times each day. Once you notice migraine symptoms, use this nasal spray; if your symptoms do not fully improve or if your migraine returns, you can take another dose 2 hours after you took your first one.

Patients should not take more than 5mg in a single dose and no more than 10mg within 24 hours.

How long does Zomig take to work?

Zomig nasal spray is quickly absorbed into your system and should start relieving your migraine symptoms within an hour of taking your first does. For some patients, this medication may take up to 2 hours before reducing headache pain. Follow all your healthcare provider’s instructions to ensure you receive the best results during treatment.

Resources:

  1. https://www.drugs.com/zomig.html
  2. https://www.healthlinkbc.ca/medications/zolmitriptan-spray-nasal
  3. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=84b51cb9-83f3-4a49-7fa3-1adc0f963658&type=display
  4. https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/zomig-product-monograph-en.pdf

Additional information

Brand Name:

Zomig Nasal Spray

Scientific Name:

Zolmitriptan, Zolmitriptan Nasal Spray

Other Names:

Zolmist Nasal Spray, Zomig Nasal Spray

Strength(s):

2.5mg, 5mg

Quantities Available:

6doses, 7doses, 12doses, 18doses, 21doses, 28doses

Formulation:

Nasal Spray