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Prescription Required
Formulation : Tablet
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Pitavastatin

Prescription Required
Formulation : Tablet
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Indications

Livalo is a brand-name cholesterol-lowering medication called an HMG-CoA reductase inhibitor or statin and used as an adjunct to diet to reduce low-density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia or mixed dyslipidemia.

Livalo works by blocking an enzyme in the liver responsible for producing LDL (Low Density Lipoprotein) cholesterol. In addition to taking Livalo, it is recommended to follow a heart-healthy diet. Livalo is a prescription medication and should only be taken as directed by a healthcare provider.

Uses and Dosage

General Dosage and Administration Information

  • Take LIVALO orally once daily with or without food at the same time each day.
  • Individualize the dose of LIVALO according to patient characteristics, the goal of therapy, and response.
  • After initiation or upon titration of LIVALO, analyze lipid levels after 4 weeks and adjust the dosage accordingly.

Recommended Dosage for Adults and Pediatric Patients Aged 8 Years and Older

  • The recommended starting LIVALO dosage is 2 mg once daily.
  • The maximum recommended dosage is LIVALO 4 mg once daily.

Recommended Dosage in Patients with Renal Impairment

  • The recommended starting dose for patients with moderate and severe renal impairment (estimated glomerular filtration rate 30 – 59 mL/minute/1.73 m2 and 15 – 29 mL/minute/1.73 m2, respectively) and patients with end-stage renal disease receiving hemodialysis is LIVALO 1 mg once daily.
  • The maximum recommended dose for these patients is LIVALO 2 mg once daily

LIVALO Dosage Adjustments Due to Drug Interactions

  • In patients taking erythromycin, do not exceed LIVALO 1 mg once daily.
  • In patients taking rifampin, do not exceed LIVALO 2 mg once daily.

Side Effects

Livalo may cause serious side effects including:

  • Unexplained muscle pain
  • Tenderness or weakness with fever
  • Unusual tiredness
  • Dark-coloured urine
  • Confusion
  • Memory problems
  • Vomiting
  • Pain in your side or lower back
  • Little or no urinating
  • Swelling
  • Rapid weight gain
  • Loss of appetite
  • Stomach pain (upper right side)
  • Tiredness
  • Clay-colored stools
  • Yellowing of the skin or eyes (jaundice)

Get medical help right away if you have any of the symptoms listed above.

The most common side effects of Livalo include:

  • Mild muscle pain
  • Pain in your arms or legs
  • Back pain
  • Diarrhea
  • Constipation

Tell the doctor if you have any side effect that bothers you or that does not go away.

Caution

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis):

Risks increase in a dose-dependent manner, with advanced age (>65), renal impairment, and inadequately treated hypothyroidism. Advise patients to promptly report unexplained muscle pain, tenderness, or weakness, and discontinue LIVALO if signs or symptoms appear.

Liver enzyme abnormalities:

Persistent elevations in hepatic transaminases can occur. Check liver enzyme tests before initiating therapy and as clinically indicated thereafter.

Form and Strength

Livalo is available in the following forms and strengths:

  • Livalo Film Coated Tablet:
    • 1mg
    • 2mg
    • 4mg
  • Pitavastatin Tablet:
    • 1mg
    • 2mg
    • 4mg

FAQ

Is Livalo (pitavastatin) better than other statins?

Livalo (pitavastatin) may be better for patients who have not tolerated other statins well and need medication with less muscle pain as a side effect.

What is Livalo (pitavastatin) used for?

Livalo (pitavastatin) is used together with diet, weight loss, and exercise to reduce the amount of bad cholesterol in your body and increase the amount of good cholesterol.

Who should not take Livalo (pitavastatin)?

Livalo (pitavastatin) should not be used if you are allergic to pitavastatin, have liver disease, are pregnant or breastfeeding, or are currently taking cyclosporine.

Resources:

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022363s008s009lbl.pdf
  2. https://www.drugs.com/livalo.html
  3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=44dcbf97-99ec-427c-ba50-207e0069d6d2

Additional information

Brand Name:

Livalo

Scientific Name:

Pitavastatin

Other Names:

Alipza, Livalo, Pivasta

Strength(s):

1mg, 2mg, 4mg

Quantities Available:

30, 60, 90, 100

Formulation:

Film Coated Tablet, Tablet