Kaletra (Lopinavir/Ritonavir)

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Kaletra Brand
Dosage Quantity & Price
200/50mg
Lopinavir/Ritonavir (Generic alternate to Kaletra) Generic
Dosage Quantity & Price
200/50mg
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Table of contents:

Kaletra is a prescription medication that is used in combination with other antiretroviral medicines to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children. It contains two medications, lopinavir and ritonavir, and belongs to a class of medications called protease inhibitors. Protease inhibitors work by blocking an enzyme that is necessary for the HIV (Human Immunodeficiency Virus) to multiply and spread within the body.

Kaletra has been approved by the U.S. Food and Drug Administration for the treatment of HIV infection in adults and children over 14 days of age

Uses and Dosage

Kaletra is available in tablet form to be taken by mouth, usually once or twice daily, with or without food as directed by your doctor. Swallow the tablets whole and do not crush, break, or chew them. When taking Kaletra with didanosine, it can be taken at the same time but without food. To ensure the best effect, take the medication at the same time each day. Avoid skipping doses, taking over prescribed or stopping the medication without consulting your doctor. These actions may increase the amount of the virus, make it more difficult to treat, or worsen side effects.

The dosage will depend on your medical condition, response to treatment, and other medications you may be taking, and may be adjusted by your doctor as needed.

  • The recommended total daily dosage of Kaletra for adults is 800/200 mg, which can be given once or twice daily depending on the patient.
  • In pediatric patients 14 days and older: the once-daily dosing regimen is not recommended, and the twice-daily dose should be based on body weight or surface area.
  • For pregnant patients with no documented lopinavir-associated resistance substitutions, the recommended dosage is 400/100 mg twice daily.

Side effect

Common Side Effects of Kaletra (Lopinavir/Ritonavir):

  • Diarrhea
  • Increased fats in blood (triglycerides or cholesterol)
  • Nausea
  • Vomiting

Serious Side Effects of Kaletra (Lopinavir/Ritonavir):

  • Changes in your immune system (immune reconstitution syndrome)
  • Increase in your blood sugar levels
  • Increased bleeding in people with hemophilia
  • Increased hunger or thirst
  • Increases in certain fat (triglycerides and cholesterol) levels in your blood.
  • Kidney stones
  • Skin rash, which can be severe
  • Unusual weight loss
  • Urinate more often than usual

Form and strength

Kaletra (Lopinavir/Ritonavir) is available in the following forms and strength:

Kaletra: Film Coated Tablet

  • 200/50 mg

Lopinavir/Ritonavir: Tablet

  • 200/50 mg

Caution

  • Risk of loss of virologic response, resistance, and cross-resistance (kaletra warning label).
  • Kaletra may cause potential hepatotoxicity (liver damage)
  • Serious side effects including the risk of developing pancreatitis, liver problems, or abnormal heart rhythm.
  • Kaletra may cause serious side effects such as liver problems, high blood sugar, and changes in body fat distribution.
  • Kaletra may interact with other medications, including blood thinners, cholesterol-lowering drugs, and migraine medications.
  • It should not be used in people with severe liver or kidney disease.
  • Kaletra may cause a skin rash that could be a sign of a serious allergic reaction.
  • It may increase the risk of bleeding in people with hemophilia.
  • Kaletra may have a negative impact on bone density and increase the risk of osteoporosis. Taking kaletra should consult with their healthcare provider and carefully read and follow the medication's instructions and warnings.
  • Do not use Kaletra during pregnancy unless necessary and should only be used under close medical supervision.

Frequently Asked Questions (FAQ)

Can pregnant patients take Kaletra?

For pregnant patients with no documented lopinavir-associated resistance substitutions, the recommended dosage is 400/100 mg twice daily.

Can Kaletra interact with other medications?

Yes, Kaletra may interact with other medications, including blood thinners, cholesterol-lowering drugs, and migraine medications.

Does Kaletra need to be refrigerated?

Kaletra tablets may be stored at room temperature, while the oral solution should be refrigerated at 2-8°C (36-46°F) and may be kept at room temperature below 25°C (77°F) for up to 1 month.

Can I take Kaletra with food?

Kaletra should be taken with food to improve absorption.

Can I take Kaletra with food?

Kaletra should be taken with food to improve absorption.

Resources

It's important to purchase Kaletra from verified Canadian pharmacy.

Additional information

Generic name:

Lopinavir/Ritonavir

Formulation:

Film Coated Tablet, Tablet

Strength(s):

200/50mg

Quantities Available:

60, 120

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