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Indications

Mirapex is a dopaminergic medication used to treat symptoms of Parkinson’s disease which include stiffness, tremors, muscle spasms, and poor muscle control. This medication can also help treat restless leg syndrome (RLS).

Pramipexole is a non-ergolinic dopamine agonist that stimulates striatal neuronal firing rates through activating dopamine receptors. This action helps Mirapex support muscle health and treat symptoms of Parkinson’s disease such as muscle stiffness, tremors, and spasms.

This Parkinson’s medication is generally well-tolerated and may benefit the mental health of patients as well as their motor symptoms. Mirapex has been found to effectively treat both Parkinson’s disease and moderate to severe restless less syndrome.

Uses and Dosage

The dose prescribed for Mirapex will vary depending on the individual and condition being treated. Always follow your doctor’s directives and read packaging labels carefully when taking medications.

  • Swallow tablet whole
  • Take with or without food
  • If Mirapex upsets your stomach, take your doses with food
  • Dosing and timing will differ between Parkinson’s disease and RLS
  • Adults with Parkinson’s usually start with 0.375mg once daily
  • Doses may increase every 5 or 7 first to 0.75mg and then in increments of 0.75mg
  • Adults shouldn’t take more than 4.5mg daily
  • Adults with RLS usually start with 0.125mg once daily before bed
  • RLS doses can increase by 0.125mg every 4 to 7 days
  • Most adults take a RLS maintenance dose of 0.5mg 2 to 3 hours before bed
  • Do not suddenly stop taking Mirapex to avoid withdrawal
  • Store at room temperature away from moisture, heat, and light

Side Effects

Mirapex may cause some side effects to occur while it affects your dopamine levels and receptors. Consult with your doctor for more information regarding symptoms you may encounter when taking pramipexole.

Common Mirapex side effects:

  • Muscle spasm or weakness
  • Drowsiness, dizziness, weakness
  • Confusion, memory problems
  • Dry mouth
  • Nausea, constipation
  • Increased urination
  • Insomnia, unusual dreams

Those using pramipexole may have an increase in sexual urges, unusual urges to gamble or other intense urges. Discuss with your doctor if you encounter this effect.

Serious Side Effects

Some more serious adverse reactions may occur when taking pramipexole. Stop taking Mirapex and call your doctor if you develop any of the following side effects:

  • Light-headed feeling like you might pass out
  • Hallucinations (visual or auditory)
  • Extreme drowsiness, suddenly and unexpectedly falling asleep
  • Tremors, twitching, or uncontrollable muscle movements
  • Unexplained muscle pain, tenderness, or weakness
  • Vision problems
  • Uncontrollable posture changes (involuntary bending forward of your neck, bending forward at the waist, tilting sideways when you sit, stand, or walk)

Confusion or hallucinations may be more likely to occur in older adults taking Mirapex.

Allergic Reactions

Do not take Mirapex if you are allergic to pramipexole. If you develop signs of an allergic reaction, stop taking this medication and contact your doctor.

Mirapex allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat

Cautions

Do not drink alcohol while taking Mirapex because it can cause dangerous side effects when combined with pramipexole.

Some people who take Mirapex can fall asleep during typical daytime activities, even if they feel alert, such as working, talking, eating, or driving. Tell your doctor if you have any issues with drowsiness or sleepiness during the day.

Be cautious when driving or performing hazardous activities that require you to be awake and alert when using this medication.

You may encounter an increase in urges including sexual urges or those to gamble while taking pramipexole. Discuss with your doctor if you think you have intense or unusual urges while using this medication.

To avoid dizziness and prevent falls, move slowly when standing from a seated or lying position.

If you take Mirapex for restless leg syndrome (RLS), contact your doctor if you notice that your symptoms get worse, if they occur in the morning or earlier than usual, or if you notice symptoms in your hands or arms.

To ensure your safety in taking Mirapex, tell your doctor if you have ever had any of the following:

  • Low blood pressure
  • Dizziness after standing too quickly
  • Daytime drowsiness
  • Kidney disease
  • Problems controlling your muscle movements

Patients with Parkinson’s who take this medication may have a higher risk of developing skin cancer. Consult with your doctor about risks and which symptoms to monitor.

If you use Mirapex with drugs that cause drowsiness, this effect can be worsened. Ask your doctor before taking opioid medication, sleeping pills, muscle relaxers, or medicine for anxiety or seizures.

Some drugs can interact with pramipexole and cause adverse reactions. Tell your doctor about all the medications you take, including over the counter medicine, vitamins, and herbal products, but especially any of the following:

  • Cimetidine
  • Metoclopramide
  • Medicine for mental illness (chlorpromazine, droperidol, fluphenazine, and others)

The effects of pramipexole on unborn babies are unclear. Tell your doctor if you are pregnant or plan to become pregnant while using Mirapex.

Mirapex may or may not pass into breast milk. Consult with your doctor before breastfeeding while taking this medication.

Form and Strength

This dopaminergic medication is available in the form of extended-release tablets.

Mirapex extended-release tablet strengths:

  • 1mg
  • 0.25mg
  • 0.125mg

The 0.25 and 1mg extended-release tablets are available in quantities of 100 while the 0.125mg ones are available in quantities of 30 or 90.

FAQ

Does Mirapex make you tired?

A common side effect of Mirapex is drowsiness or tiredness. Some people who take this medication can experience sudden tiredness that causes them to fall asleep unexpectedly during the day. Consult your doctor to learn more about the risks and benefits of taking Mirapex for Parkinson’s disease or RLS.

How long before bed should you take Mirapex?

When taking Mirapex to treat restless leg syndrome (RLS), it is recommended that you take your dose 2 to 3 hours before bed. This allows the drug to work into your system and reach peak concentrations to help you fall asleep and combat symptoms.

Resources:

  1. https://pubmed.ncbi.nlm.nih.gov/21721909/
  2. https://pubmed.ncbi.nlm.nih.gov/20297857/
  3. https://pubmed.ncbi.nlm.nih.gov/20839895/
  4. https://www.drugs.com/mirapex.html
  5. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e2902ed1-cfeb-4815-adc3-129c577917a1

Additional information

Brand Name:

Mirapex

Scientific Name:

Pramipexole

Other Names:

Mirapexin, Pexola, Pramipex, Pramipexole, Pramipexole Dihydrochloride

Strength(s):

0.088mg, 0.5mg, 0.18mg, 0.25mg, 0.35mg, 0.125mg, 1.5mg, 1mg

Quantities Available:

30, 90, 100

Formulation:

Extended Release Tablet, Tablet