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Indications

Daliresp (roflumilast) is a prescription medication used to treat severe chronic obstructive pulmonary disease (COPD) in adults with symptoms of chronic bronchitis and a history of exacerbations.

Daliresp works by reducing inflammation in the airways to help prevent COPD exacerbations and taken as a once-daily pill and should be used only as directed by a medical professional.

Use and Dosage

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

Use this medication regularly to get the most benefit from it. This medication works best if used at evenly spaced intervals. To help you remember, use it at the same time each day. Do not increase your dose, use this medication more frequently, or stop using it without first consulting your doctor.

To reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations: 500 mcg orally once a day, with or without food.

Side Effects

Common side effects include:

• Nausea
• Dizziness
• Headache
• Abdominal pain
• Diarrhea
• Loss of appetite
• Minor weight loss

In most cases, the side effects caused by this oral drug are mild and will resolve even without intervention. If the adverse reactions persist or worsen, consult your doctor or any healthcare professional.

Severe side effects include:

• Fast or irregular heartbeat
• Shaking or tremors
• Trouble sleeping
• Unusual/extreme weight loss
• Mental/mood changes (i.e., suicidal thoughts or behavior)

This is not a complete list of Daliresp side effects.

Cautions

Before taking roflumilast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, cancer, heart disease (such as heart failure), current/past infections (such as tuberculosis, herpes), mental/mood disorders (depression, thoughts of suicide), unexplained/extreme weight loss, immune system disorders (such as lupus, HIV).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you dizzier. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Daliresp is available in the following form and strengths:

• Daliresp Tablet:
  • 250mcg
  • 500mcg
• Roflumilast Tablet:
  • 500mcg

FAQ

When is the best time to take this medication?

You may take it any time of the day or depending on your physician’s recommendation.

Does this medication cause weight loss?

This drug may cause minor weight loss.

How should I store this medication?

You may store the tablets at room temperature, away from direct sunlight.

Resources:

1. https://www.ema.europa.eu/en/medicines/human/EPAR/daliresp
2. https://www.drugs.com/daliresp.html#dosage
3. https://www.webmd.com/drugs/2/drug-155809/daliresp-oral/details
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351880/