Safely Buy Xigduo XR ( Dapagliflozin/Metformin Hcl ) from Canada Prescriptions Plus.

Indications

Xigduo is a diabetes medication used to lower and control your blood sugar levels to treat adults with type 2 diabetes mellitus. This medication also lowers your risk of kidney disease or death due to heart problems as well as your risk of becoming hospitalized for heart failure for patients with both type 2 diabetes and chronic kidney disease.

This medicine combines dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, with metformin, a biguanide. Dapagliflozin reduces glucose reabsorption and increases the amount of glucose that is excreted in your urine. Metformin improves your blood sugar tolerance while reducing the amount of glucose that is absorbed by your intestines and that is produced by your liver.

Thanks to these actions, Xigduo XR helps lower and maintain your blood sugar levels to improve your type 2 diabetes condition, especially when taken alongside a treatment program including diet and exercise.

Dosage and Administration

The dose of Xigduo XR that is prescribed will vary depending on the individual being treated. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best results during treatment. Do not change your dose or suddenly stop taking this medication.

• Swallow tablet whole, do not crush or chew
• Take with food at the same time each day
• You may need to adjust your dose if you are under stress including fever, trauma, infection, or surgery
• Ensure that you follow your prescribed diet and exercise program during treatment
• Continue taking Xigduo as prescribed, even if you feel well
• Store at room temperature away from children and pets

To treat type 2 diabetes mellitus:

• Adults previously taking metformin at night should skip their last dose before starting Xigduo
• Patients not already taking dapagliflozin should start by taking 5mg once daily
• Doses can increase gradually as needed and tolerated
• Adults should not take more than 10mg of dapagliflozin and 2000mg of metformin

To prevent heart failure and kidney disease:

• Most adults are recommended to take 10mg of dapagliflozin once daily
• Do not take more than 10mg dapagliflozin and 2000mg metformin

Side Effects

Xigduo XR may cause you to develop some side effects while lowering and controlling your blood sugar levels. Talk to your healthcare provider to learn more about any symptoms that you may experience during treatment.

Common Xigduo XR side effects:

• Genital infections
• Headache
• Nausea, vomiting, diarrhea
• Runny or stuffy nose, sore throat

Side effects may be more likely to occur if you are 65 years or older while taking Xigduo XR.

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Xigduo XR. Contact your healthcare provider right away if you notice any of the following side effects:

• Little or no urination
• Bladder infection symptoms (pain or burning when you urinate, increased urination, bloody urine, fever, pain in your back or pelvis)
• Dehydration (dizziness, weakness, light-headedness, faintness)
• High levels of acid in your blood (nausea, vomiting, stomach pain, confusion, unusual drowsiness, trouble breathing)
• Lactic acidosis (unusual muscle pain, difficulty breathing, stomach pain, vomiting, irregular heartbeat, dizziness, coldness, feeling tired or weak)

Seek immediate medical attention if you develop signs of a genital infection, including burning, itching, unusual odour or discharge, pain, tenderness, redness, or swelling of your genitals or rectal area as well as a fever or general ill-feeling. Symptoms of such an infection may worsen quickly.

Allergic Reactions

Do not take Xigduo XR if you are allergic to dapagliflozin, metformin, or any other ingredient used in the extended-release tablets. Stop using this medication and call your healthcare provider right away if you develop any of the following signs of an allergic reaction:

• Hives
• Trouble breathing
• Swelling of your face, lips, tongue, or throat

Cautions

• Do not use Xigduo XR if you have severe kidney disease or diabetic ketoacidosis.
• Xigduo is designed to lower your blood sugar levels to treat type 2 diabetes mellitus in adults and should not be taken by those with type 1 diabetes.
• To ensure your safety when taking Xigduo, tell your healthcare provider if you have ever had any of the following:
  • Liver or kidney disease
  • Low blood pressure
  • Bladder infection or problems with urinating
  • Heart problems, low blood pressure
  • Problems with your pancreas including surgery
  • If you follow a low salt diet
• During treatment with Xigduo XR, you may develop lactic acidosis which is a condition where a dangerous amount of lactic acid builds in your blood. You may be more likely to develop this if you have other preexisting conditions, a severe infection, chronic alcoholism, or if you are older than 65. Seek medical attention if you develop unusual muscle pain, difficulty breathing, stomach pain, dizziness, coldness, or if you feel very tired or weak.
• In rare instances, Xigduo may lead to the development of a serious genital infection. Seek medical attention if you notice any burning, itching, odour, unusual discharge, pain, tenderness, redness, or swelling of your genital or rectal area as well as a fever or general ill-feeling.
• Follow your healthcare provider’s instructions very carefully if you take Xigduo XR while pregnant. Controlling your blood sugar levels during pregnancy is very important, but using this medication during the second or third trimester of pregnancy may affect your unborn baby.
• Xigduo may stimulate ovulation and increase the risk of unplanned pregnancy. Discuss your risk with your healthcare provider before beginning treatment.
• Do not breastfeed while taking Xigduo XR.
• Some drugs may interact with Xigduo and cause adverse effects. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
  • Carbonic anhydrase inhibitors (topiramate, zonisamide, and more)
  • Cimetidine, ranolazine, vandetanib and other drugs that reduce metformin clearance
  • Insulin or insulin secretagogues
  • Thiazide medicines and diuretics
  • Corticosteroids
  • Estrogens and oral contraceptives
  • Phenytoin
  • Nicotinic acid
  • Calcium channel blocking medicines
  • Isoniazid
  • Lithium
• Avoid drinking alcohol during treatment with Xigduo because it can cause your blood sugar to lower farther and could increase your risk of developing lactic acidosis.
• When standing from a seated or laying position, avoid becoming dizzy by moving slowly.
• Xigduo XR is not an approved treatment method for anyone under the age of 18.

Form and Strength

This diabetes medicine is available in the form of extended-release tablets.

• Xigduo XR tablet strengths:
  • 10mg dapagliflozin/500mg metformin
  • 5/1000mg
  • 10/1000mg

The 10/500mg Xigduo XR tablets are available in quantities of 28 and 84 while the 5/1000mg tablets are available in groups of 56 and 112 and the 10/1000mg XR tablets are available in quantities of 84.

FAQ

Is it better to take Xigduo in the morning or evening?

Xigduo XR is often recommended to be taken once each morning with food, but your healthcare provider will suggest a time of day in which you should take your dose for the best therapeutic results for you. If you are directed to take Xigduo in the morning and have previously taken dapagliflozin tablets at night, you should skip your last dose before starting this medication to avoid having too much in your system.

What does Xigduo do to the body?

Xigduo XR combines two drugs, dapagliflozin and metformin, to lower your blood sugar levels by increasing the amount of glucose that is excreted in your urine while lowering the amount that is absorbed and produced by your body. The two drugs function together to lower and maintain your glucose levels to help treat type 2 diabetes mellitus.

Resources:

1. https://www.drugs.com/xigduo-xr.html
2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ac8a0f7b-9f69-4495-abbc-3a47cd75a859&type=display
3. https://dailymed.nlm.nih.gov/dailymed/medguide.cfm?setid=ac8a0f7b-9f69-4495-abbc-3a47cd75a859