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Indications

Seroquel XR is an antipsychotic medication used to treat symptoms of schizophrenia and bipolar disorder in both adults and children. This medication is also used to treat major depressive disorder in adults.

Quetiapine fumarate is an atypical antipsychotic that reduces symptoms of schizophrenia, manic and depressive episodes of bipolar disorder, and depressive symptoms of major depressive disorder. Thanks to its inhibition of certain dopamine and serotonin receptors in your brain to increase the availability and maintain a healthy balance of the chemicals in your brain.

Dosage and Administration

The dose of Seroquel XR that is prescribed will vary depending on the individual and mental condition being treated. Follow all directions offered by your healthcare provider and read packaging instructions carefully to ensure the best therapeutic results during treatment. Do not change your Seroquel dose on your own.

  • Swallow tablets whole, do not crush or chew
  • Take without food or after a light meal
  • Take once a day in the evening

To treat schizophrenia in adults and adolescents:

  • Adults should start by taking 300mg daily and increase in intervals of a day in increments up to 300mg depending on tolerability
  • Most adults take between 400 and 800mg once daily as maintenance monotherapy
  • Adolescents aged 13 to 17 should take 50mg on day one followed by 100mg the next day and then increase in increments of 100mg each day until an effective dose is reached
  • Most adolescents take maintenance doses of 400 to 800mg daily
  • Adults and adolescents should not take more than 800mg each day

To treat manic or mixed bipolar I disorder episodes:

  • Seroquel XR can be used as monotherapy or alongside lithium or divalproex in adults
  • Adults should start by taking 300mg on day one followed by 600mg the next day and then 400 to 800mg starting on day 3
  • Adult maintenance doses range between 400 and 800mg each day and should not exceed 800mg daily
  • Children and adolescents aged 10 to 17 should start by taking 50mg on day one, followed by 100mg on day two and then increase by 100mg each following day until effective
  • Maintenance doses for children and adolescents range from 400 to 600mg a day and should not exceed 600mg daily

To treat depressive episodes of bipolar disorder:

  • Adults should start by taking 50mg a day on day one and then 100mg the next day followed by increases of 100mg each day until an effective dose is reached
  • Most adults take a maintenance dose of 300mg and should not take more than 300mg daily

Maintenance treatment for bipolar I disorder:

  • Adults should take between 400 and 800mg once daily alongside lithium or divalproex

To treat MDD:

  • Adults should take Seroquel alongside antidepressant medications to treat MDD
  • Most adults start by taking 50mg for the first two days of treatment followed by 150mg on the third day
  • Maintenance doses range from 150 to 300mg once daily and should not exceed 300mg a day

Side Effects

Seroquel XR may cause some side effects to develop while altering the balance of chemicals in your brain. Speak with your healthcare provider to learn more about any symptoms that you may experience during treatment.

Common Seroquel XR side effects:

  • Drowsiness, fatigue
  • Dry mouth
  • Constipation
  • Dizziness
  • Increased appetite
  • Upset stomach
  • Weight gain
  • Difficulty moving
  • Issues with speech or langue
  • Stuffy nose
  • Vomiting
  • increased heartrate

Serious Side Effects

Some more serious adverse effects may occur when taking Seroquel XR. Stop using this medication and contact your doctor if you notice any of the following symptoms:

  • Stroke (especially in elderly patients with dementia)
  • Neuroleptic malignant syndrome (high fever, excessive sweating, rigid muscles, confusion, changes in breathing, heartbeat, and blood pressure)
  • Falls that may cause serious injuries
  • High blood sugar levels (increased thirst, increased need to urinate, feeling hungry, tiredness, weakness, upset stomach, nausea, confusion, fruity breath odour)
  • Increased cholesterol and triglyceride levels
  • Uncontrollable muscle movements in your face, tongue, body
  • Lower blood pressure (light-headedness, fainting)
  • Increased blood pressure in children and adolescents
  • Low white blood cell count (fever, flu-like symptoms, infection)
  • Cataracts
  • Seizures
  • Abnormal thyroid tests
  • Increased prolactin levels
  • Sleepiness, drowsiness
  • Difficulty thinking and performing normal activities
  • Increased body temperature
  • Difficulty swallowing

Allergic Reactions

Do not take Seroquel XR if you are allergic to quetiapine fumarate or any of the other listed tablet ingredients. Stop using this medication and call your doctor if you notice any signs of an allergic reaction.

Seroquel XR allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling in face or throat
  • Fever
  • Sore throat
  • Burning eyes
  • Skin pain
  • Red or purple rash that blisters or peels

Cautions

Do not take Seroquel XR if you have dementia-related psychosis. Older patients with this condition who take any antipsychotic medications, including Seroquel, have an increased risk of death.

Children, adolescents, and young adults who take antidepressant medications have an increased risk of developing suicidal thoughts and behaviours. Monitor your symptoms and report any new or worsening suicidal thoughts to your healthcare provider.

To ensure your safety when taking Seroquel, tell your healthcare provider if you have ever had any of the following:

  • Liver disease
  • Heart problems
  • High or low blood pressure
  • Low white blood cell counts
  • Abnormal thyroid tests or prolactin levels
  • Constipation, trouble urinating
  • Enlarged prostate
  • Seizure
  • Glaucoma, cataracts
  • High cholesterol or triglycerides
  • Diabetes
  • Trouble swallowing

Tell your healthcare provider if you are pregnant or plan to become pregnant during treatment with Seroquel XR. Using any antipsychotic medication, including Seroquel, in the last three months of pregnancy may lead to withdrawal symptoms, breathing issues, feeding problems, fussiness, tremors, and limp or stiff muscles in your newborn. Do not stop taking this medication without first consulting your healthcare provider and following their advice.

Do not breastfeed while taking Seroquel XR.

Seroquel XR may temporarily affect women’s ability to conceive.

Avoid drinking alcohol during treatment with Seroquel XR to avoid an increase in adverse reactions.

Avoid driving or performing any hazardous activities until you know how this medication affects you. Seroquel XR can cause you to become dizzy or drowsy which can cause falls, accidents, and injuries.

When standing from a seated or laying position, move slowly to avoid becoming dizzy.

Drink plenty of water to avoid becoming dehydrated or overheated when exercising or out in hot weather because Seroquel XR can make it easier for you to develop heat stroke.

Some drugs may interact with Seroquel XR and cause unwanted reactions. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:

  • Ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, and other CYP3A4 inhibitors
  • CYP3A4 inducers like phenytoin, carbamazepine, rifampin, St. John’s wort, and others
  • Anticholinergic drugs
  • Heart and blood pressure medications
  • Levodopa
  • Dopamine agonists

Form and Strength

This antipsychotic medication is available in the form of extended-release tablets.

Seroquel extended-release tablet strengths:

  • 50mg
  • 150mg
  • 200mg
  • 300mg
  • 400mg

The 50, 150, and 200mg Seroquel XR tablets are available in quantities of 50, 60, 100, and 120 while the 300mg tablets are available in groups of 100 and 180 and the 400mg ones are available in quantities of 50, 60, and 100.

FAQ

How long does it take for Seroquel XR to start working?

Seroquel XR is easily absorbed by your system and should begin taking effect within a few weeks of treatment. Full effects may take up to 2 or 3 months and are dependent on the individual and type of mental condition that is being treated.

When should I take Seroquel extended release?

You can take your dose of Seroquel XR at any time without decreasing the medication’s effectiveness, however you should take your dose at the same time each day. A common side effect of the medication is drowsiness, which can be minimized by taking your dose in the evening before bed. Taking Seroquel with food may also diminish possible gastrointestinal effects. Take your medication as directed by your healthcare provider.

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Additional information

Brand Name:

Seroquel XR

Scientific Name:

Quetiapine, Quetiapine Fumarate SR

Other Names:

Quetiapine XL, Quetiapine XR, Qutan SR, Qutipin SR, Seroquel XL, Seroquel XR

Strength(s):

50mg, 100mg, 150mg, 200mg, 300mg, 400mg

Quantities Available:

50, 60, 100, 120

Formulation:

Extended Release Tablet