Synvisc (Hylan G-F 20)

SYNVISC is injected directly into the knee joint by a healthcare professional. It's usually given once every week for three weeks.

SYNVISC-One is given as a single injection.

Your doctor may tell you to apply ice to your knee after you receive your injection of SYNVISC.

SYNVISC Overdose

A healthcare professional typically administers SYNVISC in a medical setting, so you're unlikely to experience an overdose.

But if you suspect an overdose, contact a poison control center or emergency room immediately.

Missed Dose of SYNVISC

Call your healthcare provider if you miss an appointment to receive your SYNVISC injection.

Common Side Effects of SYNVISC

Tell your doctor if any of the following side effects become severe or don't go away:

• Mild pain, warmth, swelling, stiffness, or puffiness at the injection site
• Itching or skin irritation around the knee
• Muscle pain or trouble walking
• Fever, chills, or nausea
• Numbness or tingly feeling
• Tiredness
• Headache
• Dizziness

Serious Side Effects of SYNVISC

Tell your doctor right away if you experience any of the following serious side effects:

• Signs of an allergic reaction, which may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat
• Fast, pounding heartbeat
• Severe headache

You shouldn't receive an injection of SYNVISC if you have an infection in your knee or on the skin surrounding your knee.

Before receiving this treatment, tell your doctor if you have or have had:

• Blood clots
• Circulation problems in your legs
• Skin infections
• An allergy to hylan G-F 20, birds, feathers, or egg products

Call your doctor immediately if you experience severe pain or swelling around the knee after receiving an injection of SYNVISC.

You'll need to avoid strenuous activities such as jogging or high-impact sports for at least two days after your treatment with SYNVISC. You should also avoid standing for longer than one hour at a time for at least 48 hours after your injection.

SYNVISC should only be injected in the knee. The safety and effectiveness of the treatment in other areas of the body hasn't been established.

This treatment typically isn't used in people under age 21. 

Pregnancy and SYNVISC

It's not known whether SYNVISC could harm an unborn baby.

Tell your doctor if you're pregnant or plan to become pregnant before receiving this therapy.

It's also not known whether SYNVISC could pass into breast milk.

Don't breastfeed a baby while receiving SYNVISC injections without first talking to your physician.

Other medications may interact with SYNVISC.

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.