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Indications

Oesclim is a transdermal patch that contains estradiol, a form of estrogen.

Estradiol is used for hormone replacement therapy (HRT) in women to relieve symptoms associated with menopause and to prevent osteoporosis.

Use and Dosage

A new patch should be applied to your skin on the same days twice a week (i.e., the patch should be changed once every 3 to 4 days). Depending on the individual, your doctor may advise you to use the patches continuously or in a cyclic schedule (approximately 3 weeks of treatment with patches followed by approximately one week without patch use). Talk to your doctor if you are not sure whether you are using an estradiol patch continuously or with a patch-free period.

Women who have not had a hysterectomy (removal of their uterus) must also take progestin while they are taking this medication to prevent adverse effects associated with the use of estrogen.

The patch is often applied to the buttocks, lower abdomen, or hip. Many women have found that less skin irritation occurs when the patch is applied to the buttocks. Talk to your doctor or pharmacist about the most appropriate site to apply the patch. Do not apply the patch to your breasts. Do not apply patches to the same site on the skin twice in a row.

Choose a clean and dry area of intact skin that is not oily, damaged, irritated, or exposed to the sun. To avoid irritation, do not apply to the same site on the skin 2 times in a row.

Tear open the pouch containing the patch rather than using scissors – if you accidentally cut the patch, it will be useless.

Remove the protective layer. Apply the patch to the selected area immediately. Avoid touching the adhesive.

Use your fingers to hold the patch in place for about 10 seconds and make sure that the patch is affixed to your skin, especially around its edges.

When changing the patch, remove the old one carefully, fold it in half so that the adhesive sides stick together, and throw it away or bring it to the pharmacy for proper disposal. Keep it out of the reach of children or pets. If adhesive remains on your skin, rub it off gently.

Bathing, showering, swimming, or other contact with water does not affect the patch. However, hot water or steam may cause the patch to loosen. If your patch falls off, try to reapply it. If that does not work, apply a new patch.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

Use this medication exactly as prescribed by your doctor. If you forget to apply or change your patch, change it as soon as you remember. If it is close to the day when you normally change your patch, still apply it but change the patch again on your usual day and continue with your regular schedule. Do not wear 2 patches at once. If you are not sure what to do after forgetting to apply or change the patch, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children. Do not store the patches out of the pouch.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to estradiol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
• Signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance
• Signs of a blood clot – sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs
• Swelling or tenderness in your stomach
• Jaundice (yellowing of the skin or eyes)
• Memory problems, confusion, unusual behavior
• Unusual vaginal bleeding, pelvic pain
• Lump in your breast
• Nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, or lack of energy

Common estradiol side effects may include:

• Nausea, vomiting, diarrhea, stomach cramps
• Mood changes, sleep problems (insomnia)
• Cold symptoms such as stuffy nose, sinus pain, sore throat
• Weight gain
• Headache, back pain, dizziness
• Breast pain
• Darkening of the skin or skin rash
• Thinning scalp hair
• Vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding

This is not a complete list of side effects and others may occur.

Cautions

• Do not use this medication if you:
  • Are allergic to estradiol or any ingredients of this medication
  • Are breast-feeding
  • Are or may be pregnant
  • Have, have had, or may have breast cancer
  • Have a blood clotting disorder
  • Have a history of known or suspected estrogen-dependent tumors (e.g., endometrial cancer)
  • Have active phlebitis (inflamed varicose veins)
  • Have classical migraines (migraines with aura)
  • Have endometrial hyperplasia (thickening of the inner lining of the uterus)
  • Have liver dysfunction or disease where liver function tests have not returned to normal
  • Have or have ever had liver tumors
  • Have or have had a stroke, heart attack, or coronary heart disease
  • Have or have had blood clots in the legs or lungs, or coronary thrombosis
  • Have partial or complete loss of vision from eye disease related to circulation problems
  • Have porphyria
  • Have unusual vaginal bleeding that has not been checked by a doctor

Forms and Strengths

Oesclim Patch is available in the following forms and strengths:

• Oesclim Patch:
  • 25 mcg
  • 50 mcg

FAQ

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention. Overdose can result in nausea, vomiting and vaginal bleeding.

What to avoid?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine.

Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.

Resources:

1. https://www.medbroadcast.com/drug/getdrug/oesclim
2. https://www.drugs.com/estradiol.html#side-effects
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233503/