Safely Buy Zoladex LA ( Goserelin ) from Canada Prescriptions Plus.

Indications

Zoladex LA is a medication that contains goserelin, which belongs to a group of medicines called LHRH analogues.

Zoladex LA is used for the treatment of certain types of cancer. Here is some information about its use and dosage.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start using goserelin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is an implant that slowly releases hormones into your body. It is placed by a health care professional by injection under the skin of the lower abdomen below the navel. The implant itself will be completely absorbed into the body over weeks or months.

Receive this medication as directed by your doctor. The 3.6-milligram syringe is usually injected every 4 weeks. The 10.8-milligram syringe is usually injected every 12 to 13 weeks. Follow the dosing schedule carefully to get the most benefit from it. To help you remember, mark your calendar to keep track of when to receive the next dose. Do not stop this medication without your doctor’s approval.

The dosage is based on your medical condition and response to treatment.

During the first few weeks of treatment, your hormone levels will increase before they decrease. This is a normal response by your body to this drug. This may cause new or worsening symptoms (such as increased pain, and increased difficulty urinating in men) for the first few weeks. Tell your doctor right away about these symptoms. See also the Side Effects section.

In women, menstrual periods should stop when this medication is used regularly. Tell your doctor promptly if regular periods continue after 2 months of treatment with goserelin.

Usually, this medication will not need to be removed because the implant will be slowly and completely absorbed by your body. However, in the unlikely event that you have serious side effects or other problems, your doctor may remove this medication.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to goserelin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

When you start treatment with goserelin, your tumor symptoms may get worse for a short time. Worsening of a prostate tumor may increase pressure on your spinal cord or urinary tract. Tell your doctor right away if you have symptoms such as back pain, painful or difficult urination, loss of movement in any part of your body, or loss of bowel or bladder control.

Call your doctor at once if you have:

• Pain, bruising, swelling, redness, oozing, or bleeding where the implant was injected
• Dizziness, trouble breathing, feeling light-headed (like you might pass out)
• High blood sugar – increased thirst, increased urination, dry mouth, fruity breath odor
• High calcium levels – confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss
• Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
• Signs of a blood clot – sudden numbness or weakness on one side of the body, chest pain, problems with vision or speech, pain or swelling in one leg

Common goserelin side effects may include:

• Hot flashes, sweating
• Painful urination
• Mood changes, increased or decreased interest in sex
• Changes in sexual function, fewer erections than normal
• Headache
• Swelling in your hands or feet
• Vaginal dryness, itching, or discharge
• Changes in breast size
• Acne, mild skin rash or itching

This is not a complete list of side effects and others may occur. 

Cautions

• Before using goserelin, tell your doctor or pharmacist if you are allergic to it; or to LHRH or LHRH-like hormones (such as triptorelin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: unexplained abnormal vaginal bleeding, diabetes, long-term alcohol use, smoking, personal or family history of bone loss (osteoporosis), heart disease (such as heart attack), high cholesterol/triglyceride levels, stroke, urinary blockage problem (in men), spinal cord problem (in men), mental/mood problems (such as depression).
• If you have diabetes, this drug may make it harder to control your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet.
• Goserelin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, and fainting) that need medical attention right away.
• The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using goserelin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
• Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using goserelin safely.
• Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).
• Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using goserelin. Goserelin may harm an unborn baby. Ask about reliable non-hormonal forms of birth control (such as condoms, and diaphragm with spermicide) while using this medication and for 12 weeks after the last dose or until the return of your period. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
• It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this medication. Consult your doctor before breastfeeding.

Forms and Strengths

Zoladex LA is available in the following forms and strengths:

• Zoladex LA Disposable Syringe:
  • 10.8 mg

FAQ

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment to receive your goserelin implant.

What happens if I overdose?

Since the goserelin implant contains a specific amount of the medicine, you are not likely to receive an overdose.

What should I avoid while receiving goserelin?

Avoid drinking alcohol. It can increase your risk of bone loss while you are being treated with goserelin.

Avoid smoking, which can increase your risk of bone loss, stroke, or heart problems.

Resources:

1. https://www.medbroadcast.com/drug/getdrug/zoladex-la#contraindications
2. https://www.webmd.com/drugs/2/drug-7103/zoladex-subcutaneous/details
3. https://www.drugs.com/goserelin.html#side-effects