Sinemet CR (Carbidopa/Levodopa)

Sinemet CR (Carbidopa-Levodopa) Medication Information

Uses

Sinemet CR is dopamine synthetic that is used to treat Parkinson’s disease and parkinsonism. 

Dosage

The tablets are available in several different strengths:

• 25-100 mg
• 50-200 mg

Side Effects

The most common side effects of Sinemet CR include:

• Abdominal pain
• Changes in blood pressure
• Heartburn
• Weight loss
• Somnolence
• Anxiety
• Gait abnormalities
• Memory impairment
• Rash 

Speak with your doctor for a full list of side effects that apply to you if you are taking Sinemet.

Precautions

Sinemet can affect multiple organ systems, so it is recommended that liver, heart and kidney function be monitored along with blood count regularly during treatment.

Patients with wide-angle glaucoma should use caution when being treated with Sinemet.

Dopamine agents like Sinemet can cause somnolence, so patients should be monitored during their initial treatment. 

Interactions

The most common drug interaction with Sinemet CR included:

• Antihypertensives
• MAOIs
• TCAs
• Phenothiazine
• Butyrophenones
• Risperidone
• Metoclopramide 

Speak with your doctor for more information and before starting a new medication with Sinemet. 

Storage

Store below 86ºF. Store Sinemet in a tightly closed container. 

Pharmacist Tips

• Sinemet can affect several organ systems, so monitoring blood work during treatment is important.
• If you have a dose adjustment to Sinemet CR you will need to be monitored closely. 
• Sinemet should be given as a whole or half tablet. 

Sinemet CR FAQs

What is the best way to take Sinemet?

It is generally recommended that Sinemet be taken on an empty stomach. 

What are the symptoms of too much Sinemet?

Some symptoms of taking too much Sinemet include dizziness, agitation, and irregular heartbeat.

What foods should I avoid with Sinemet?

Foods that are high in protein, fiber, or fat can decrease drug absorption. 

How quickly will Sinemet take effect?

The ingredients in Sinemet CR will be released over 4-6 hours. 

Does Sinemet help with walking?

Sinemet has been found to help with freezing, but it will not help with balance. 

Related Drugs

• Azilect
• Exelon
• Mirapex
• Requip
• Requip XL
• Sinemet
• Stalevo
• Tasmar

Reference:

Sinemet CR {package insert}. Princeton, NJ: Bristol-Myers Squibb.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/019856s025lbl.pdf