Safely Buy Jentadueto ( Linagliptin/Metformin ) from Canada Prescriptions Plus.

Indications

Jentadueto is a medication used for the treatment of type 2 diabetes mellitus. It is a combination therapy that contains two diabetes medicines, linagliptin and metformin hydrochloride.

Linagliptin belongs to a class of medicines called DPP-4 inhibitors, which work by increasing the level of incretin hormones in the body that help lower blood sugar levels.

Metformin works by helping to lower blood sugar levels by decreasing the amount of glucose produced and released by the liver and by increasing the body’s sensitivity to insulin.

Jentadueto is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Use and Dosage

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking linagliptin/metformin each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.

Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Jentadueto: (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, fast/slow or irregular heartbeats, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

• A severe autoimmune reaction – itching, blisters, or breakdown of the outer layer of skin
• Severe or ongoing pain in your joints
• Symptoms of heart failure – shortness of breath (even while lying down), swelling in your legs or feet, or rapid weight gain

Common Jentadueto side effects include:

• Sore throat
• Sinus pain or stuffy nose
• Diarrhea

This is not a complete list of side effects and others may occur.

Cautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to linagliptin or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, severe breathing problems (such as obstructive lung disease, severe asthma), liver disease, a disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones), blood problems (such as anemia, vitamin B12 deficiency).

Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing lactic acidosis, pancreatitis, and low blood sugar.

High fever, “water pills” (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause dehydration and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Older adults may be more sensitive to the side effects of this drug, especially low blood sugar or lactic acidosis.

Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).

Metformin passes into breast milk. It is unknown if linagliptin passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Jentadueto is available in the following form and strengths:

• Jentadueto Tablet:
  • 2.5/500 mg
  • 2.5/850 mg
  • 2.5/1000 mg

FAQ

What happens if I miss a dose?

Take the medicine (with food) as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention. You may have severely low blood sugar (extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure).

What to avoid?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

Resources:

1. https://www.webmd.com/drugs/2/drug-159449/jentadueto-oral/details
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/201281S014S018lbl.pdf
3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/201281S014S018lbl.pdf
4. https://www.drugs.com/jentadueto.html#side-effects