Safely Buy Synjardy ( Empagliflozin/metformin hcl ) from Canada Prescriptions Plus.

Indications

Synjardy is a diabetes medication used to control blood sugar levels in those with type 2 diabetes mellitus. The medication is also used to lower diabetes or heart disease patients’ risk of death from heart attack, stroke, or heart failure.

This oral diabetes medication combines empagliflozin and metformin to support your kidney’s secretion of glucose from your bloodstream and lowering its production in your liver. The two anti-diabetic agents support glycemic control by acting on separate areas, such as urinary excretion and liver production of glucose.

Thanks to its combination of empagliflozin and metformin, Synjardy effectively improves glycemic control in patients with type 2 diabetes. The medication has been found to be well-tolerated with a low risk of causing hypoglycemia. The drug combination also helps reduce pill burden for better quality of life.

Uses and Dosage

The dose prescribed for Synjardy will vary depending on the individual being treated. Follow all your doctor’s instructions and read packaging labels carefully for the best results throughout treatment.

• Swallow tablets whole
• Take twice a day with meals
• Those switching from metformin monotherapy should start Synjardy at a similar daily metformin dosage and 10mg of empagliflozin each day
• For those switching from empagliflozin, start by taking the same empagliflozin dosage and 1000mg of metformin daily
• Those changing from a different medication combining these drugs, start Synjardy at the same daily doses for empagliflozin and metformin
• Adults are recommended to take 10mg of empagliflozin each day
• Adults should not take more than 25mg of empagliflozin or 2000mg of metformin daily
• Tell doctors you take Synjardy, you may need to suspend treatment to get an x-ray or CT scan
• Check your blood pressure regularly throughout treatment
• Monitor ketone levels in your urine and contact your doctor if you have a high amount
• Synjardy may be combined with a treatment plan including diet, exercise and weight control
• Store at room temperature away from moisture and heat
• Keep away from children and pets

Side Effects

Synjardy may cause some side effects to develop while improving the secretion of glucose into your urine and reducing its production in your liver. Speak with your doctor for more information regarding any symptoms that you may experience when using empagliflozin and metformin.

Common Synjardy side effects:

• Low blood sugar
• Indigestion, stomach pain, gas, nausea, vomiting, diarrhea
• Bladder infection
• Yeast infection in women
• Headache, weakness
• Runny or stuffy nose, sore throat

Side effects may be more likely to occur in older adults using Synjardy.

Serious Side Effects

Some more serious adverse reactions may occur when taking empagliflozin and metformin. Stop using this diabetes medication and call your doctor if you develop any of the following side effects:

• Light-headed feeling like you might pass out
• Dehydration (dizziness, confusion, feeling thirsty, less urination)
• Ketoacidosis (nausea, vomiting, stomach pain, confusion, unusual drowsiness, trouble breathing)
• Lactic acidosis (unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heartbeat, dizziness, feeling cold, feeling weak or tired)
• Bladder infection (pain or burning when you urinate, blood in your urine, pain in pelvis or back)

Seek immediate medical attention if you have any signs of a serious genital infection such as burning, itching, odour, unusual discharge, pain, tenderness, redness or swelling of genital or rectal area, fever, feeling unwell. These symptoms may worsen quickly, call your doctor as soon as you notice any of them.

Allergic Reactions

Do not take Synjardy if you are allergic to empagliflozin or metformin. If you notice any signs of an allergic reaction, stop using this medication and contact your doctor right away.

Synjardy allergy symptoms may include:

• Hives
• Difficulty breathing
• Swelling of face, lips, tongue, or throat

Cautions

Do not use Synjardy if you have moderate to severe kidney disease, if you are on dialysis, or if you are on diabetic ketoacidosis.

Synjardy may cause you to develop lactic acidosis, a serious condition involving the build-up of lactic acid in your blood. Seek immediate medical attention if you notice any mild symptoms including muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heartbeats, dizziness, or feeling very weak or tired.

Tell your doctor right away if you are sick with vomiting or diarrhea, or if you are eating or drinking less than usual.

Avoid drinking alcohol while taking Synjardy because it can increase your risk of developing lactic acidosis.

When getting up from a seated or lying position, move slowly to avoid getting dizzy.

In rare instances this medication could cause serious infections in the penis or vagina. Seek immediate attention if you have burning, itching, odour, unusual discharge, pain, tenderness, redness or swelling of the genital area, fever, or if you feel unwell.

To ensure your safety when taking Synjardy, tell your doctor if you have any of the following:

• Liver or kidney disease
• Bladder infection or urinary problems
• Congestive heart failure, a heart attack or stroke
• Genital infection
• Pancreatic problems, including surgery
• If you follow a low salt diet
• If you are aged 65 years or older

Synjardy may cause harm if used during the second or third trimester of pregnancy, but controlling diabetes is very important when pregnant. Consult your doctor if you are pregnant or plan to become pregnant while taking Synjardy and follow their instructions carefully.

Do not breastfeed while taking Synjardy.

Metformin may stimulate ovulation in premenopausal women which increases the risk of an unplanned pregnancy. Discuss your risk with your doctor before starting treatment.

Some drugs may interact with empagliflozin or metformin and cause adverse reactions. To avoid this, tell your doctor about all the medications you take, including over the counter medicine, but especially any of the following:

• Insulin or another oral diabetes medication
• Diuretic medicine

Synjardy is not an approved treatment for anyone under the age of 18.

Form and Strength

This type 2 diabetes medication is available in tablet form.

Synjardy tablet strengths:

• 5mg empagliflozin / 500mg metformin
• 12.5 / 1000mg

Both Synjardy tablet strengths are available in quantities of 180 while the 12.5 / 1000mg tablets are also available in quantities of 60.

FAQ

Can I drink alcohol while taking Synjardy?

You should avoid drinking alcohol frequently or large amounts during short periods of time during your Synjardy treatment. Consult with your doctor to determine your risk because alcohol consumption may increase your chances of developing serious side effects such as lactic acidosis or low blood sugar.

When is the best time to take Synjardy?

Synjardy should be taken twice a day with meals to improve its absorption and tolerability. You can take your Synjardy doses whenever it is most convenient for you as long as you stay consistent, but once in the morning with breakfast and in the evening with dinner is recommended.

Resources:

1. https://pubmed.ncbi.nlm.nih.gov/27819159/
2. https://pubmed.ncbi.nlm.nih.gov/30068236/
3. https://www.drugs.com/synjardy.html
4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0fdd0255-0055-65f3-b2c0-db8fbb87beae