Safely Buy Invokamet XR ( Canagliflozin/Metformin Hcl XR ) from Canada Prescriptions Plus.

Indications

Invokamet XR is a medication that combines two active ingredients: canagliflozin and metformin. It is primarily used to help lower blood sugar levels in adults with type 2 diabetes mellitus.

When combined with a proper diet and exercise, Invokamet XR can help improve glycemic control.

Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, while metformin is a biguanide. Canagliflozin works by reducing the reabsorption of glucose by the kidneys, leading to increased glucose excretion in the urine.

Metformin helps to lower blood glucose levels by reducing the production of glucose in the liver and improving the body’s response to insulin.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily with the morning meal. Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release all of the drugs at once, increasing the risk of side effects. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Tell your doctor if your condition does not get better or if it gets worse (your blood sugar is too high or too low).

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odour, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or not feeling well. These symptoms may get worse quickly.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Stop taking Invokamet XR and call your doctor right away if you have unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Serious side effects include:

• New pain, tenderness, sores, ulcers, or infections in your legs or feet
• Little or no urination
• A light-headed feeling, like you might pass out
• High potassium level–nausea, weakness, tingly feeling, chest pain, irregular heartbeats, or muscle weakness
• Ketoacidosis (too much acid in the blood) –nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing
• Signs of a bladder infection–pain or burning when you urinate, urine that looks cloudy, or pain in the pelvis or back
• Older adults may be more likely to get dehydrated or have kidney problems while taking this medicine
• You may be more likely to have a broken bone while using this medicine. Talk with your doctor about how to avoid the risk of fractures

Common side effects of Invokamet XR may include:

• Urinating more than usual
• Headache or weakness
• Gas, stomach pain, or indigestion
• Nausea or vomiting
• Diarrhea

This is not a complete list of side effects and others may occur.

Cautions

• Before taking this medication, tell your doctor or pharmacist if you are allergic to canagliflozin or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, obstructive lung disease), blood problems (such as anemia, vitamin B12 deficiency), dehydration, low blood pressure, heart failure, kidney disease, liver problems, use/abuse of alcohol, blood mineral imbalances (such as high levels of potassium), yeast infections in the vagina or penis.
• Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.
• You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
• Limit alcohol while using this medication because it can increase your risk of developing lactic acidosis, low blood sugar, or a high ketone level.
• High fever, “water pills” (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause dehydration and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.
• It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Also, if you are eating less or are not able to eat due to these conditions or any illness, this can lead to a high ketone level while you are taking this medication. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar or ketone testing.
• Older adults may be at greater risk for side effects such as low blood sugar, dehydration, lactic acidosis, dizziness/fainting (usually when standing), or bone loss while using this drug.
• Metformin can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.
• During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
• Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).
• Metformin passes into breast milk in small amounts. It is unknown if canagliflozin passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Invokamet XR is available in the following form and strengths:

• Canagliflozin-metformin tablet:
  • 50/500mg

FAQ

What happens if I miss a dose?

Take the medicine (with food) as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention. You may have severely low blood sugar (extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure).

What should I avoid while taking Invokamet XR?

Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

Resources:

1. https://www.drugs.com/mtm/invokamet-xr.html#side-effects
2. https://www.fda.gov/safety/medical-product-safety-information/invokana-invokamet-invokamet-xr-canagliflozin-medwatch-safety-alert-boxed-warning-about-risk-leg-and
3. https://www.webmd.com/drugs/2/drug-172573/invokamet-xr-oral/details
4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/205879s000lbl.pdf