Safely Buy Angeliq ( Drospirenone/Estradiol ) from Canada Prescriptions Plus.

Indications

Angeliq is a female hormone medication used to treat menopause symptoms including hot flashes and vaginal dryness, burning, and irritation.

The medication combines two female hormones: drospirenone, a progestin, and estradiol, an estrogen, to help regulate and maintain the female reproductive system. The estrogen/progestin mixture allows Angeliq to help balance missing levels of hormones to reduce symptoms of menopause.

Dosage and Administration

The dose of Angeliq that is prescribed will vary depending on the individual and severity of menopause symptoms being treated. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best results during treatment.

• Swallow tablets whole
• Take at the same time each day with or without food
• To treat vasomotor menopause symptoms, most patients start by taking 0.25mg drospirenone/0.5mg estradiol or 0.5/1mg once daily
• To treat vulvar and vaginal atrophy, patients usually take 0.5/1mg once a day
• Doses may be increased until relief from symptoms is achieved
• Those who are not taking estrogen can start treatment any time
• Patients taking hormone therapy, whether continuous or cyclic, should complete their current cycle before starting treatment with Angeliq
• Treatment may need to temporarily stop if you need a major surgery, tell your surgeons and healthcare providers you take Angeliq
• Self-examine your breasts for lumps and have regular mammograms during treatment
• Store at room temperature away from children and pets

Side Effects

Angeliq may cause some side effects to develop while affecting your hormone levels. Speak with your healthcare provider to learn more about any symptoms that you may experience during treatment.

Common Angeliq side effects:

• Dizziness, feeling light-headed
• Headache
• Upset stomach, bloating
• Irritability
• Changes in your sleep patterns
• Nausea
• Changes in weight
• Increased or decreased sex drive
• Change in vaginal discharge
• Breast tenderness

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Angeliq. Call your healthcare provider right away if you develop any of the following side effects:

• Changes in your mood or behaviours including depression and memory loss
• Breast lumps
• Nipple discharge
• Swelling hands or feet
• Unusual vaginal bleeding (spotting, breakthrough bleeding, prolonged or returning bleeding)
• Jaundice
• Stomach pain
• New or worsening seizures
• Muscle weakness
• Signs of worsening control of diabetes (increased thirst or urination)
• High potassium levels (muscle weakness, slow or irregular heartbeat)

In rare instances, Angeliq has been found to cause the development of blood clots which can lead to serious and sometimes fatal problems including deep vein thrombosis, pulmonary embolism, stroke, and heart attacks. Seek immediate medical attention if you experience any of the following symptoms:

• pain, swelling, or warmth in your groin or calf
• Tingling, numbness, or weakness in your arms or legs
• Sudden shortness of breath
• Coughing blood
• Pain in your chest, jaw, or left arm
• Unusual sweating
• Sudden dizziness or fainting
• Confusion
• Difficulty speaking
• Weakness on one side of your body
• Sudden changes in vision
• Severe and unusual headaches

Allergic Reactions

Do not use Angeliq if you are allergic to drospirenone, estradiol, spironolactone, or any of the other tablet ingredients. Contact your healthcare provider immediately if you notice any of the following signs of an allergic reaction:

• Rash
• Itching or swelling of your face, lips, tongue, or throat
• Dizziness
• Difficulty breathing

Cautions

• Angeliq is designed to treat menopause symptoms and should not be used by any premenopausal female or anyone who is pregnant.
• Do not take Angeliq if you have any of the following conditions:
  • Liver disease
  • History of estrogen- or progestin-dependent breast or endometrial cancer
  • Liver tumours or a history thereof
  • Severe kidney disease
  • Severe high levels of triglycerides
  • Endometrial hyperplasia
  • Abnormal vaginal bleeding that is undiagnosed
  • Arterial thromboembolic disease or history of such including stroke, myocardial infarction, or coronary heart disease
  • Classical migraines
  • Deep vein thrombosis, pulmonary embolism, or another type of venous thromboembolism
  • High risk of developing venous or arterial thrombosis
  • Vision loss caused by ophthalmic vascular disease
• Angeliq may cause you to become dizzy or light-headed. Avoid drinking alcohol while using this medication because it can worsen these effects.
• Consult with your healthcare provider before taking potassium supplements or using salt substitutes with potassium during treatment because Angeliq can cause your potassium levels to increase.
• Patients who are nearsighted or who wear contact lenses may experience vision problems or have trouble wearing contacts during treatment with Angeliq. Speak with your healthcare provider if you experience any of these issues.
• Angeliq may cause you to develop dark areas of skin. You should avoid long and direct exposure to the sun and artificial UV rays because sunlight can worsen the effect.
• Do not smoke while taking Angeliq because tobacco can increase your risk of developing a stroke, blood clot, high blood pressure, or heart attacks.
• To ensure your safety when taking Angeliq, tell your healthcare provider if you have ever had any of the following:
  • Vaginal bleeding with an unknown cause
  • Breast, ovarian, or uterine cancer
  • Blood clotting disorders
  • Current or a history of blood clots
  • Stroke
  • Liver or kidney disease
  • Problems with your adrenal glands
  • History of certain swelling disorders such as angioedema
  • Asthma
  • Diabetes
  • Seizures
  • Migraine headaches
  • Heart disease
  • Underactive thyroid
  • Certain hormone problems including hypoparathyroidism
  • Mineral imbalance
  • Mental or mood disorders
  • High blood pressure during pregnancy
  • Jaundice during pregnancy or during past use of estrogen
  • Uterine fibroids, endometriosis, or other uterus problems
  • High blood cholesterol or fat levels
  • Gallbladder disease
  • Certain metabolic disorders including porphyria
  • Lupus
• Small amounts of Angeliq can pass into breast milk and can affect the quality and amount that is produced. Consult with your healthcare provider before breastfeeding while using this medication.
• Angeliq may lead to the development of uterine cancer. Contact your healthcare provider right away if you develop any unusual or unexplained vaginal bleeding.
• Some drugs may interact with Angeliq and cause adverse reactions. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
  • Aromatase inhibitors like anastrozole or exemestane
  • Atazanavir, cobicistat
  • Corticosteroids like prednisone
  • Ospemifene
  • Raloxifene
  • Tamoxifen
  • Tizanidine
  • Tranexamic acid
  • Warfarin
  • Aliskiren
  • ACE inhibitors including enalapril and lisinopril
  • Angiotensin receptor blockers like losartan or valsartan
  • Heparin
  • Nonsteroidal anti-inflammatory drugs like ibuprofen or naproxen
  • Potassium sparing diuretic medicines
  • Azole antifungal medications like itraconazole
  • Macrolide antibiotics such as erythromycin
  • Rifamycins like rifabutin
  • St John’s wort
  • Seizure medications including carbamazepine or phenytoin

Form and Strength

This menopause medication is available in tablet form.

• Angeliq tablet strengths:
  • 1mg drospirenone/1mg estradiol
  • 2/1mg

The 1/1mg Angeliq tablets are available in quantities of 28 and 84 while the 2/1mg tablets are available in quantities of 84.

FAQ

When is the best time to take Angeliq?

Angeliq can be taken with or without food at any time of day without losing efficacy. Ensure that you take your daily doses at the same time each day for the best therapeutic response during treatment. Follow all directions of use offered by your healthcare provider for the best results.

What are the benefits of taking Angeliq?

Angeliq is designed to treat symptoms of menopause including hot flashes as well as vaginal dryness and irritation.

The medication provides a progestin and an estrogen form of female hormones to replace levels that you are missing while undergoing menopause. Speak with your healthcare provider to discuss this medicine in more detail and determine how it may treat your menopause symptoms.

Resources:

1. https://www.drugs.com/angeliq.html
2. https://www.healthlinkbc.ca/medications/drospirenoneestradiol-oral
3. https://www.bayer.com/sites/default/files/2020-11/angeliq-pm-en.pdf
4. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=761834c2-6b61-4583-84c2-f1ca4a97c4f2&type=display#section-11.1