Sintrom (acenocoumarol) belongs to a group of medicines called anticoagulants (blood thinning medicines). Sintrom is used to treat and prevent blood clots blocking the blood vessels e.g. deep vein thrombosis (DVT). Sintrom does not dissolve blood clots that have already formed but it may stop the clots from becoming larger and causing more serious problems. Always take Sintrom exactly as your doctor has told you to. Sintrom should be taken as a single dose at the same time every day. Swallow your tablets whole with a drink of water. Elderly patients, patients with liver disease or severe heart failure or malnourished patients may need lower doses. Experience with blood thinning medicines including Sintrom in children and adolescents is limited. If Sintrom is used in children or adolescents, blood should be tested more often, to see how well the medicine is working. If you need any injections into your spine or as part of a scan or X-ray test or if you need minor surgery, including dental surgery, make sure you discuss your treatment with your doctor first. Tell your doctor or dentist or pharmacist at every visit that you are using Sintrom.

Manufacturer Information

Canadian Pharmacy King currently offers the brand Sintrom from Canada manufactured by Paladin. The generic Sintrom comes from India also called Acitrom manufactured by Abbott. The brand Sintrom comes in the strength of 1 mg and 4 mg tablets and the generic Acenocoumarol is available in the strength of 2 mg and 4 mg tablets.

The common side effects of Sintrom may include bleeding from the gums, unexplained bruising or nosebleeds, heavy periods, heavy bleeding from cuts or wounds, signs of bleeding inside the body such as abdominal pain, vomiting blood, bloody or black tarry stools, backache, blood in the urine, dizziness, severe headache, weakness in an arm or leg, blurred vision. Contact your doctor right away if you have a serious rare skin condition called calciphylaxis that can start with a painful skin rash but can lead to serious complications. This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Be careful when drinking alcohol as it may affect how Sintrom thins your blood. You should avoid drinking cranberry juice or taking other cranberry products, such as capsules or concentrates as this could mean you do not receive the correct amount of acenocoumarol. You should not receive any injections into your muscles whilst you are taking Sintrom as it contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor or pharmacist before taking this medicinal product. You should not take Sintrom if you: are allergic to acenocoumarol, or similar medicines to thin the blood called coumarin derivatives or to any of the ingredients in Sintrom, are pregnant or breast-feeding, are an alcoholic or have chest pain, have any mental illness for example, schizophrenia, have, or are about to have an operation on your spine, brain, eyes or any major surgery, had a stroke caused by bleeding into your brain or have bleeding problems, suffer from very high blood pressure, have stomach ulcer or any intestinal bleeding, have severe liver or kidney disease. Before taking Sintrom, inform your doctor if you: have cancer, have an infection or swelling, have a disorder affecting the absorption of food from the stomach and/or intestine, have heart failure or liver problems, have kidney problems or an overactive thyroid, are elderly, suffer from a blood disorder such as protein C or protein S deficiency, have a higher risk of bleeding.

Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines. Sintrom may interact with: protease inhibitors – medicines used to treat HIV infection, methylprednisolone, a corticosteroid used to treat various inflammatory conditions, low blood sugar levels by medicines used for diabetes, medicines used to treat epilepsy such as phenytoin, anticancer medications, inflammation or pain medicines, medicines that stop platelets from clumping together, antibiotics, vitamin E or vitamin K, medicines known to increase the activity of some liver enzymes, medicines used to treat water retention and high blood pressure.