Synjardy (Empagliflozin/metformin hcl) from Maple Leaf Medications.

What is Synjardy used for? 

Synjardy, with the generic name empagliflozin and metformin hydrochloride, is an oral medication indicated to improve glycemic control or help reduce elevated blood sugar levels among patients with type 2 diabetes mellitus. This is usually prescribed as an adjunct to proper diet and exercise. It helps prevent complications of diabetes, such as stroke, heart attack, blindness, kidney damage, loss of limbs, and nerve damage. 

This is available in Synjardy 12.5 mg/1000 mg, 12.5 mg/500 mg, 5 mg/1000 mg and 5 mg/500 mg tablet forms. 

How does Synjardy work? 

This medication is a combination of a sodium-glucose co-transporter 2 (SGLT-2) inhibitor and a biguanide. It works by reducing the renal absorption of filtered glucose and lowering the renal threshold for glucose which results in the increased excretion of glucose in the urine. It also decreases hepatic glucose production and intestinal absorption of glucose. Additionally, it improves insulin sensitivity by increasing peripheral glucose uptake and utilization. 

How to use Synjardy 

To start, read the Synjardy information leaflet that comes with this product. Do not take this maintenance drug if you have not yet fully understood the drug information and warnings printed in the guide. If you have further inquiries regarding this treatment or need additional medical advice, you can ask your doctor or pharmacist. 

Take the tablet orally. This is usually prescribed twice daily or as directed by your physician. Taking this medication with a meal is recommended. After swallowing the tablet, drink a glass of water. It is not recommended to split, crush, or chew this type of medication. 

Remember to use this diabetes drug regularly and exactly as prescribed to achieve the best results. Make a dosing schedule to avoid forgetting your doses. Do not alter your Synjardy dosing as it is based on your medical condition, other medications you are taking, and response to treatment. Additionally, you should keep taking this medication even when you feel better to avoid worsening conditions. 

Synjardy Side Effects 

Common side effects: 

-nausea 

-headache 

-diarrhea 

-indigestion 

-stomach discomfort 

-gas 

-vomiting 

-runny nose 

-sore throat 

In most cases, the side effects brought about by this medication are mild and will resolve after a while. If the adverse reactions become worse or do not get better, you should hold the tablets and consult your doctor or any healthcare professional. Furthermore, you should notify your doctor if you experience severe side effects, including: 

-signs of yeast infection in the vagina (unusual vaginal discharge, unusual odor, severe itchiness) 

-signs of urinary tract infection (fever, urgent urination, pink or bloody urine) 

-changes in urine output (signs of kidney disease)  

-signs of high blood sugar or hyperglycemia (increased urination, fruity breath, confusion, rapid breathing, drowsiness, flushing) 

-signs of low blood sugar or hypoglycemia (shaking, palpitations, sweating, blurred vision, hunger, dizziness, tingling sensation) 

-dehydration 

This is not a complete or full list of the side effects of Synjardy. 

Precautions when using Synjardy 

Before you begin to take this anti-diabetic medication, you should fully disclose your entire medical history to your physician, including breathing problems, blood disorders, kidney disease, liver disease, heart disease, alcohol abuse, or dehydration. Some conditions may directly impact how your system will respond to the medication. Also, you should talk about all the prescription drugs, nonprescription drugs, supplements, and herbal products you are taking, for they might have drug interactions with this medication. 

Be watchful for a severe allergic reaction while on this treatment. Do not take this tablet if you have a known allergy to empagliflozin, metformin, or any inactive ingredients it may contain. Immediately discontinue medication and seek emergency medical attention once you notice signs of hypersensitivity response, including trouble breathing, swelling of the face, severe dizziness, skin rashes, and hives. 

Avoid or, as much as possible, limit your consumption of alcoholic drinks. Alcohol may cause lactic acidosis, high ketone levels, and low blood sugar. It could also trigger certain adverse effects like dizziness, drowsiness, and blurred vision. 

The metformin component of this medication could cause changes to your menstrual cycle. It could promote ovulation and increase the risk of becoming pregnant. Discuss with your healthcare provider some effective birth control methods that you may need. 

Pregnancy could worsen or cause diabetes. Thus, you must talk to your physician if you are pregnant or planning to get pregnant to be able to discuss the possible changes in your treatment plan. 

Frequently Asked Questions 

What is the difference between Synjardy XR and Synjardy? 

Synjardy XR is in an extended-release form and is only being taken once daily. 

Can I use Synjardy for type 1 diabetes? 

This diabetes medication is not indicated for type 1 diabetes or diabetic ketoacidosis. 

Are there some good Synjardy alternatives? 

Some alternatives to this drug are Xigduo or Janumet. 

Does this medication cause weight loss? 

Yes, there is a direct link between Synjardy & weight loss. 

Is Synjardy over the counter? 

You need a prescription from your physician to purchase this oral medication.