Paxil (Paroxetine)
Medication information written by Dr. Larisa Roybal, PharmD
Updated - February 15, 2021
Paxil (Paroxetine) Medication Information
Uses
Paxil is a selective serotonin receptor inhibitor (SSRI) used to treat major depressive disorder, panic disorder, obsessive compulsive disorder, and other anxiety disorders.
Dosage
The tablets are available in several different strengths:
- 10 mg
- 20 mg
- 30 mg
- 40 mg
Side Effects
The most common side effects of Paxil include:
- Somnolence
- Insomnia
- Anxiety
- Constipation
- Nausea
- Diarrhea
- Decreased libido
Speak with your doctor for a full list of side effects that apply to you if you are taking Paroxetine.
Precautions
Paxil like other SSRIs can cause an increase in suicidality during the first initial treatment. It is important to monitor patients taking Paxil to ensure that they do not have any significant changes during the first month of therapy.
There was a small percentage of patients that have experienced seizures while taking Paroxetine.
It is recommended that treatment with Paxil be tapered off if it is decided that it is not longer needed.
Paxil, like other SSRIs can cause a decrease in sodium in the body. The doctor should monitor your blood chemistry when you are taking Paxil.
There is an increased risk of bleeding while taking Paroxetine.
Interactions
The most common drug interactions with Paxil are listed:
- Tryptophan
- Pimozide
- SSRIs
- SNRIs
- MAOIs
- Triptans
- Warfarin
- Cimetidine
Speak with your doctor for more information and before starting a new medication with Paroxetine.
Storage
Store at room temperature (59-86ºF).
Pharmacist Tips
- Antidepressants like Paroxetine can increase suicidal thoughts
- Paxil can be titrated to achieve the maximum benefit for each patient
- Call your healthcare provider right away if you notice any sudden changes in behavior while taking Paroxetine
Paroxetine FAQs
How long does it take for Paxil to work?
It can take up to 6-8 weeks to see the full benefit of Paxil.
What can you not take with Paxil?
It is recommended to not take other medications that affect serotonin, like SNRIs, MAOIs, and triptans. For a more complete list of medications that should not be taken with Paxil contact your doctor.
Does Paxil work right away for anxiety?
It can take up to 6-8 weeks to see the full benefit of Paroxetine for anxiety.
Is it better to take Paroxetine in the morning or at night?
The medication can be taken either in the morning or at night.
Does Paxil affect you sexually?
One of the side effects of Paroxetine is a decreased libido.
Related Drugs
Reference:
Paxil {package insert}. Research Triangle Park, NC: GlaxoSmithKline; 2008.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020031s05920710s023lbl.pdf
Author: Dr. Larisa Roybal, PharmD
Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.